The alliance of mesenchymal stem cells, bone, and diabetes

Nicola Napoli, Rocky Strollo, Angela Paladini, Silvia I. Briganti, Paolo Pozzilli, Sol Epstein

Research output: Contribution to journalArticle

Abstract

Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially alter the fate of mesenchymal stem cells, the initial precursor of the osteoblast. In this review, we describe the main factors that impair bone health in diabetic patients and their clinical impact.

Original languageEnglish
Article number690783
JournalInternational Journal of Endocrinology
Volume2014
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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  • Cite this

    Napoli, N., Strollo, R., Paladini, A., Briganti, S. I., Pozzilli, P., & Epstein, S. (2014). The alliance of mesenchymal stem cells, bone, and diabetes. International Journal of Endocrinology, 2014, [690783]. https://doi.org/10.1155/2014/690783