The Alpha-like surface proteins: An example of an expanding family of adhesins

Roberta Creti, L. Baldassarri, L. Montanaro, C. R. Arciola

Research output: Contribution to journalArticlepeer-review


The Alpha-like protein (Alp) family, repeat-containing surface proteins once thought to be important adhesion factors confined to pathogenic streptococci and enterococci, is broader than previously known. Analysis of the annotated microbial genomes has identified new potential members of the Alp family not only in other Gram- positive opportunistic pathogens but also in commensal microflora of the human gut and the skin. This finding has highlighted the importance of genome sequencing projects for unraveling in greater detail lateral gene transfer events involving virulence factors between pathogens and commensals. These should receive constant attention not only as part of infectious disease prevention programs, but also in the food and biotechnology industries.

Original languageEnglish
Pages (from-to)834-840
Number of pages7
JournalInternational Journal of Artificial Organs
Issue number9
Publication statusPublished - Sep 2008


  • Genome comparison
  • Gram-positive adhesins
  • Protein domain

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)


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