The alveolar to arterial oxygen partial pressure difference is associated with pulmonary diffusing capacity in heart failure patients

Marco Morosin, Carlo Vignati, Angela Novi, Elisabetta Salvioni, Fabrizio Veglia, Marina Alimento, Guido Merli, Susanna Sciomer, Gianfranco Sinagra, Piergiuseppe Agostoni

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5 Citations (Scopus)

Abstract

In chronic heart failure (HF), the alveolar-capillary membrane undergoes a remodeling process that negatively affects gas exchange. In case of alveolar-capillary gas diffusion impairment, arterial desaturation (SaO2) is rarely observed in HF patients. At play are 3 factors: overall pulmonary diffusing capacity (assessed as lung diffusion for CO, DLCO), global O2 consumption (VO2) and alveolar (A) to arterial (a) pO2 gradient (AaDO2). In 100 consecutive stable HF patients, DLCO, resting respiratory gases and arterial blood gases were measured to determine VO2, paO2, pAO2 and AaDO2. DLCO was poorly but significantly related to AaDO2. The correlation improved after correcting AaDO2 for VO2 (p 2 and AaDO2 were independently associated with DLCO (p 2 and pAO2. AaDO2/VO2 showed a higher gradient in patients with lower DLCO. AaDO2 increase and VO2 reduction allow preventing low SaO2 in HF patients with reduced DLCO. Accordingly, we suggest considering AaDO2 and VO2 combined and reporting AaDO2/VO2.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume233
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Pulmonary Diffusing Capacity
Partial Pressure
Heart Failure
Gases
Oxygen
Carbon Monoxide
Lung
Membranes

Keywords

  • Arterial-alveolar oxygen gradient
  • Cardiopulmonary exercise testing
  • Diffusing capacity for carbon monoxide
  • Heart failure
  • Peak VO

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

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title = "The alveolar to arterial oxygen partial pressure difference is associated with pulmonary diffusing capacity in heart failure patients",
abstract = "In chronic heart failure (HF), the alveolar-capillary membrane undergoes a remodeling process that negatively affects gas exchange. In case of alveolar-capillary gas diffusion impairment, arterial desaturation (SaO2) is rarely observed in HF patients. At play are 3 factors: overall pulmonary diffusing capacity (assessed as lung diffusion for CO, DLCO), global O2 consumption (VO2) and alveolar (A) to arterial (a) pO2 gradient (AaDO2). In 100 consecutive stable HF patients, DLCO, resting respiratory gases and arterial blood gases were measured to determine VO2, paO2, pAO2 and AaDO2. DLCO was poorly but significantly related to AaDO2. The correlation improved after correcting AaDO2 for VO2 (p 2 and AaDO2 were independently associated with DLCO (p 2 and pAO2. AaDO2/VO2 showed a higher gradient in patients with lower DLCO. AaDO2 increase and VO2 reduction allow preventing low SaO2 in HF patients with reduced DLCO. Accordingly, we suggest considering AaDO2 and VO2 combined and reporting AaDO2/VO2.",
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author = "Marco Morosin and Carlo Vignati and Angela Novi and Elisabetta Salvioni and Fabrizio Veglia and Marina Alimento and Guido Merli and Susanna Sciomer and Gianfranco Sinagra and Piergiuseppe Agostoni",
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T1 - The alveolar to arterial oxygen partial pressure difference is associated with pulmonary diffusing capacity in heart failure patients

AU - Morosin, Marco

AU - Vignati, Carlo

AU - Novi, Angela

AU - Salvioni, Elisabetta

AU - Veglia, Fabrizio

AU - Alimento, Marina

AU - Merli, Guido

AU - Sciomer, Susanna

AU - Sinagra, Gianfranco

AU - Agostoni, Piergiuseppe

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N2 - In chronic heart failure (HF), the alveolar-capillary membrane undergoes a remodeling process that negatively affects gas exchange. In case of alveolar-capillary gas diffusion impairment, arterial desaturation (SaO2) is rarely observed in HF patients. At play are 3 factors: overall pulmonary diffusing capacity (assessed as lung diffusion for CO, DLCO), global O2 consumption (VO2) and alveolar (A) to arterial (a) pO2 gradient (AaDO2). In 100 consecutive stable HF patients, DLCO, resting respiratory gases and arterial blood gases were measured to determine VO2, paO2, pAO2 and AaDO2. DLCO was poorly but significantly related to AaDO2. The correlation improved after correcting AaDO2 for VO2 (p 2 and AaDO2 were independently associated with DLCO (p 2 and pAO2. AaDO2/VO2 showed a higher gradient in patients with lower DLCO. AaDO2 increase and VO2 reduction allow preventing low SaO2 in HF patients with reduced DLCO. Accordingly, we suggest considering AaDO2 and VO2 combined and reporting AaDO2/VO2.

AB - In chronic heart failure (HF), the alveolar-capillary membrane undergoes a remodeling process that negatively affects gas exchange. In case of alveolar-capillary gas diffusion impairment, arterial desaturation (SaO2) is rarely observed in HF patients. At play are 3 factors: overall pulmonary diffusing capacity (assessed as lung diffusion for CO, DLCO), global O2 consumption (VO2) and alveolar (A) to arterial (a) pO2 gradient (AaDO2). In 100 consecutive stable HF patients, DLCO, resting respiratory gases and arterial blood gases were measured to determine VO2, paO2, pAO2 and AaDO2. DLCO was poorly but significantly related to AaDO2. The correlation improved after correcting AaDO2 for VO2 (p 2 and AaDO2 were independently associated with DLCO (p 2 and pAO2. AaDO2/VO2 showed a higher gradient in patients with lower DLCO. AaDO2 increase and VO2 reduction allow preventing low SaO2 in HF patients with reduced DLCO. Accordingly, we suggest considering AaDO2 and VO2 combined and reporting AaDO2/VO2.

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KW - Heart failure

KW - Peak VO

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