The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment

Sanne K. Meles, Marco Pagani, Dario Arnaldi, Fabrizio De Carli, Barbara Dessi, Silvia Morbelli, Gianmario Sambuceti, Cathrine Jonsson, Klaus L. Leenders, Flavio Nobili

Research output: Contribution to journalArticle

Abstract

We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in 18F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of 18F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.

Original languageEnglish
Pages (from-to)3643-3648
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

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Keywords

  • F-FDG-PET
  • Alzheimer’s disease
  • mild cognitive impairment
  • normal aging
  • principal component analysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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