The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC-InterAct Study

Ivonne Sluijs, Nita G. Forouhi, Joline W J Beulens, Yvonne T. Van Der Schouw, Claudia Agnoli, Larraitz Arriola, Beverley Balkau, Aurelio Barricarte, Heiner Boeing, H. Bas Bueno-de-Mesquita, Françoise Clavel-Chapelon, Francesca L. Crowe, Blandine De Lauzon-Guillain, Dagmar Drogan, Paul W. Franks, Diana Gavrila, Carlos Gonzalez, Jytte Halkjær, Rudolf Kaaks, Aurelie MoskalPeter Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, José R. Quirós, Fulvio Ricceri, Sabina Rinaldi, Olov Rolandsson, Carlotta Sacerdote, María José Sánchez, Nadia Slimani, Annemieke M W Spijkerman, Birgit Teucher, Anne Tjonneland, María José Tormo, Rosario Tumino, Daphne L. Van Der A, Stephen J. Sharp, Claudia Langenberg, Edith J M Feskens, Elio Riboli, Nicholas J. Wareham

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. Conclusions: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.

Original languageEnglish
Pages (from-to)382-390
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume96
Issue number2
DOIs
Publication statusPublished - Aug 1 2012

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Dairy Products
Type 2 Diabetes Mellitus
Cheese
Cultured Milk Products
Yogurt
Meta-Analysis
Milk
Eating
Prospective Studies
Education
Incidence

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Sluijs, I., Forouhi, N. G., Beulens, J. W. J., Van Der Schouw, Y. T., Agnoli, C., Arriola, L., ... Wareham, N. J. (2012). The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC-InterAct Study. American Journal of Clinical Nutrition, 96(2), 382-390. https://doi.org/10.3945/ajcn.111.021907

The amount and type of dairy product intake and incident type 2 diabetes : Results from the EPIC-InterAct Study. / Sluijs, Ivonne; Forouhi, Nita G.; Beulens, Joline W J; Van Der Schouw, Yvonne T.; Agnoli, Claudia; Arriola, Larraitz; Balkau, Beverley; Barricarte, Aurelio; Boeing, Heiner; Bueno-de-Mesquita, H. Bas; Clavel-Chapelon, Françoise; Crowe, Francesca L.; De Lauzon-Guillain, Blandine; Drogan, Dagmar; Franks, Paul W.; Gavrila, Diana; Gonzalez, Carlos; Halkjær, Jytte; Kaaks, Rudolf; Moskal, Aurelie; Nilsson, Peter; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Quirós, José R.; Ricceri, Fulvio; Rinaldi, Sabina; Rolandsson, Olov; Sacerdote, Carlotta; Sánchez, María José; Slimani, Nadia; Spijkerman, Annemieke M W; Teucher, Birgit; Tjonneland, Anne; Tormo, María José; Tumino, Rosario; Van Der A, Daphne L.; Sharp, Stephen J.; Langenberg, Claudia; Feskens, Edith J M; Riboli, Elio; Wareham, Nicholas J.

In: American Journal of Clinical Nutrition, Vol. 96, No. 2, 01.08.2012, p. 382-390.

Research output: Contribution to journalArticle

Sluijs, I, Forouhi, NG, Beulens, JWJ, Van Der Schouw, YT, Agnoli, C, Arriola, L, Balkau, B, Barricarte, A, Boeing, H, Bueno-de-Mesquita, HB, Clavel-Chapelon, F, Crowe, FL, De Lauzon-Guillain, B, Drogan, D, Franks, PW, Gavrila, D, Gonzalez, C, Halkjær, J, Kaaks, R, Moskal, A, Nilsson, P, Overvad, K, Palli, D, Panico, S, Quirós, JR, Ricceri, F, Rinaldi, S, Rolandsson, O, Sacerdote, C, Sánchez, MJ, Slimani, N, Spijkerman, AMW, Teucher, B, Tjonneland, A, Tormo, MJ, Tumino, R, Van Der A, DL, Sharp, SJ, Langenberg, C, Feskens, EJM, Riboli, E & Wareham, NJ 2012, 'The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC-InterAct Study', American Journal of Clinical Nutrition, vol. 96, no. 2, pp. 382-390. https://doi.org/10.3945/ajcn.111.021907
Sluijs, Ivonne ; Forouhi, Nita G. ; Beulens, Joline W J ; Van Der Schouw, Yvonne T. ; Agnoli, Claudia ; Arriola, Larraitz ; Balkau, Beverley ; Barricarte, Aurelio ; Boeing, Heiner ; Bueno-de-Mesquita, H. Bas ; Clavel-Chapelon, Françoise ; Crowe, Francesca L. ; De Lauzon-Guillain, Blandine ; Drogan, Dagmar ; Franks, Paul W. ; Gavrila, Diana ; Gonzalez, Carlos ; Halkjær, Jytte ; Kaaks, Rudolf ; Moskal, Aurelie ; Nilsson, Peter ; Overvad, Kim ; Palli, Domenico ; Panico, Salvatore ; Quirós, José R. ; Ricceri, Fulvio ; Rinaldi, Sabina ; Rolandsson, Olov ; Sacerdote, Carlotta ; Sánchez, María José ; Slimani, Nadia ; Spijkerman, Annemieke M W ; Teucher, Birgit ; Tjonneland, Anne ; Tormo, María José ; Tumino, Rosario ; Van Der A, Daphne L. ; Sharp, Stephen J. ; Langenberg, Claudia ; Feskens, Edith J M ; Riboli, Elio ; Wareham, Nicholas J. / The amount and type of dairy product intake and incident type 2 diabetes : Results from the EPIC-InterAct Study. In: American Journal of Clinical Nutrition. 2012 ; Vol. 96, No. 2. pp. 382-390.
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T1 - The amount and type of dairy product intake and incident type 2 diabetes

T2 - Results from the EPIC-InterAct Study

AU - Sluijs, Ivonne

AU - Forouhi, Nita G.

AU - Beulens, Joline W J

AU - Van Der Schouw, Yvonne T.

AU - Agnoli, Claudia

AU - Arriola, Larraitz

AU - Balkau, Beverley

AU - Barricarte, Aurelio

AU - Boeing, Heiner

AU - Bueno-de-Mesquita, H. Bas

AU - Clavel-Chapelon, Françoise

AU - Crowe, Francesca L.

AU - De Lauzon-Guillain, Blandine

AU - Drogan, Dagmar

AU - Franks, Paul W.

AU - Gavrila, Diana

AU - Gonzalez, Carlos

AU - Halkjær, Jytte

AU - Kaaks, Rudolf

AU - Moskal, Aurelie

AU - Nilsson, Peter

AU - Overvad, Kim

AU - Palli, Domenico

AU - Panico, Salvatore

AU - Quirós, José R.

AU - Ricceri, Fulvio

AU - Rinaldi, Sabina

AU - Rolandsson, Olov

AU - Sacerdote, Carlotta

AU - Sánchez, María José

AU - Slimani, Nadia

AU - Spijkerman, Annemieke M W

AU - Teucher, Birgit

AU - Tjonneland, Anne

AU - Tormo, María José

AU - Tumino, Rosario

AU - Van Der A, Daphne L.

AU - Sharp, Stephen J.

AU - Langenberg, Claudia

AU - Feskens, Edith J M

AU - Riboli, Elio

AU - Wareham, Nicholas J.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. Conclusions: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.

AB - Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. Conclusions: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.

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