The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC-InterAct Study

Ivonne Sluijs, Nita G. Forouhi, Joline W J Beulens, Yvonne T. Van Der Schouw, Claudia Agnoli, Larraitz Arriola, Beverley Balkau, Aurelio Barricarte, Heiner Boeing, H. Bas Bueno-de-Mesquita, Françoise Clavel-Chapelon, Francesca L. Crowe, Blandine De Lauzon-Guillain, Dagmar Drogan, Paul W. Franks, Diana Gavrila, Carlos Gonzalez, Jytte Halkjær, Rudolf Kaaks, Aurelie MoskalPeter Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, José R. Quirós, Fulvio Ricceri, Sabina Rinaldi, Olov Rolandsson, Carlotta Sacerdote, María José Sánchez, Nadia Slimani, Annemieke M W Spijkerman, Birgit Teucher, Anne Tjonneland, María José Tormo, Rosario Tumino, Daphne L. Van Der A, Stephen J. Sharp, Claudia Langenberg, Edith J M Feskens, Elio Riboli, Nicholas J. Wareham

Research output: Contribution to journalArticle

Abstract

Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. Conclusions: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.

Original languageEnglish
Pages (from-to)382-390
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume96
Issue number2
DOIs
Publication statusPublished - Aug 1 2012

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Sluijs, I., Forouhi, N. G., Beulens, J. W. J., Van Der Schouw, Y. T., Agnoli, C., Arriola, L., Balkau, B., Barricarte, A., Boeing, H., Bueno-de-Mesquita, H. B., Clavel-Chapelon, F., Crowe, F. L., De Lauzon-Guillain, B., Drogan, D., Franks, P. W., Gavrila, D., Gonzalez, C., Halkjær, J., Kaaks, R., ... Wareham, N. J. (2012). The amount and type of dairy product intake and incident type 2 diabetes: Results from the EPIC-InterAct Study. American Journal of Clinical Nutrition, 96(2), 382-390. https://doi.org/10.3945/ajcn.111.021907