The amplification of TCR signaling by dynamic membrane microdomains

Antonella Viola

Research output: Contribution to journalArticlepeer-review


Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell responses to infectious agents. Recently, many laboratories have suggested that TCR triggering might be compartmentalized in plasma membrane microdomains called rafts. Results on the role of lipid rafts as signaling units in TCR triggering suggest that rafts might be used by T cells to fine-tune their immune responsiveness.

Original languageEnglish
Pages (from-to)322-327
Number of pages6
JournalTrends in Immunology
Issue number6
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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