The amygdala mediates the impairing effect of the selective κ-opioid receptor agonist U-50,488 on memory in CD1 mice

Claudio Castellano, Vincenzo Libri, Martine Ammassari-Teule

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the selective κ-opioid receptor agonist U-50,488 on passive avoidance behaviour was studied in CD1 mice bearing lesions of the amygdaloid complex. The results have shown that post-trial injections of U-50,488 in unoperated mice as well as lesions of the amygdaloid complex in untreated mice decreased retention performances. No further impairment was observed in lesioned mice treated with U-50,488, indicating that amygdala is involved in the mediation of the effects of κ-opioid receptor agonists on memory. The possibility that κ-opioid receptors could modulate the memory retention of CD1 mice by influencing their emotional state is discussed.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalBehavioural Brain Research
Volume30
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • Amygdaloid lesion
  • CD1 mouse
  • Passive avoidance
  • U-50,488

ASJC Scopus subject areas

  • Behavioral Neuroscience

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