TY - JOUR
T1 - The amygdala mediates the impairing effect of the selective κ-opioid receptor agonist U-50,488 on memory in CD1 mice
AU - Castellano, Claudio
AU - Libri, Vincenzo
AU - Ammassari-Teule, Martine
PY - 1988
Y1 - 1988
N2 - The effect of the selective κ-opioid receptor agonist U-50,488 on passive avoidance behaviour was studied in CD1 mice bearing lesions of the amygdaloid complex. The results have shown that post-trial injections of U-50,488 in unoperated mice as well as lesions of the amygdaloid complex in untreated mice decreased retention performances. No further impairment was observed in lesioned mice treated with U-50,488, indicating that amygdala is involved in the mediation of the effects of κ-opioid receptor agonists on memory. The possibility that κ-opioid receptors could modulate the memory retention of CD1 mice by influencing their emotional state is discussed.
AB - The effect of the selective κ-opioid receptor agonist U-50,488 on passive avoidance behaviour was studied in CD1 mice bearing lesions of the amygdaloid complex. The results have shown that post-trial injections of U-50,488 in unoperated mice as well as lesions of the amygdaloid complex in untreated mice decreased retention performances. No further impairment was observed in lesioned mice treated with U-50,488, indicating that amygdala is involved in the mediation of the effects of κ-opioid receptor agonists on memory. The possibility that κ-opioid receptors could modulate the memory retention of CD1 mice by influencing their emotional state is discussed.
KW - Amygdaloid lesion
KW - CD1 mouse
KW - Passive avoidance
KW - U-50,488
UR - http://www.scopus.com/inward/record.url?scp=0023749281&partnerID=8YFLogxK
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U2 - 10.1016/0166-4328(88)90168-4
DO - 10.1016/0166-4328(88)90168-4
M3 - Article
C2 - 2846004
AN - SCOPUS:0023749281
VL - 30
SP - 259
EP - 263
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
IS - 3
ER -