TY - JOUR
T1 - The angiogenic factor PIGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension
AU - Carnevale, Daniela
AU - Pallante, Fabio
AU - Fardella, Valentina
AU - Fardella, Stefania
AU - Iacobucci, Roberta
AU - Federici, Massimo
AU - Cifelli, Giuseppe
AU - DeLucia, Massimiliano
AU - Lembo, Giuseppe
PY - 2014/11/20
Y1 - 2014/11/20
N2 - Hypertension is a health problem affecting over 1 billion people worldwide. How the immune systemgets activated under hypertensive stimuli to contribute to blood pressure elevation is a fascinating enigma. Here we showed a splenic role for placental growth factor (PlGF), which accounts for the onset of hypertension, through immune system modulation. PlGF repressed the expression of the protein Timp3 (tissue inhibitor of metalloproteinases 3), through the transcriptional Sirt1-p53 axis. Timp3 repression allowed costimulation of Tcells and their deployment toward classical organs involved in hypertension. We showed that the spleen is an essential organ for the development of hypertension through anoradrenergic drive mediated by the celiac ganglionefferent. Overall, we demonstrate that PlGF mediates the neuroimmune interaction in the spleen, organizing a unique and nonredundant response that allows the onset of hypertension.
AB - Hypertension is a health problem affecting over 1 billion people worldwide. How the immune systemgets activated under hypertensive stimuli to contribute to blood pressure elevation is a fascinating enigma. Here we showed a splenic role for placental growth factor (PlGF), which accounts for the onset of hypertension, through immune system modulation. PlGF repressed the expression of the protein Timp3 (tissue inhibitor of metalloproteinases 3), through the transcriptional Sirt1-p53 axis. Timp3 repression allowed costimulation of Tcells and their deployment toward classical organs involved in hypertension. We showed that the spleen is an essential organ for the development of hypertension through anoradrenergic drive mediated by the celiac ganglionefferent. Overall, we demonstrate that PlGF mediates the neuroimmune interaction in the spleen, organizing a unique and nonredundant response that allows the onset of hypertension.
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U2 - 10.1016/j.immuni.2014.11.002
DO - 10.1016/j.immuni.2014.11.002
M3 - Article
C2 - 25517614
AN - SCOPUS:84912085339
VL - 41
SP - 737
EP - 752
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 5
ER -