The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and neuropathy recognize the N-glycolylneuraminic acid containing gangliotetrahexosyl oligosaccharide

Marinella Carpo, Eduardo Nobile-Orazio, Vanna Chigorno, Sandro Sonnino

Research output: Contribution to journalArticlepeer-review

Abstract

We found that serum antibodies present in the serum of patients with motor neuron disease and neuropathy, which were previously shown to react with the oligosaccharide chain of ganglioside GM1(Neu5Ac), can be recognized and titred using the N-glycolylneuraminic acid containing monosialo-gangliotetrahexosylceramide, GM1(Neu5Gc), which is not a component of normal human cells. The antibody-antigen reaction was abolished by immunoabsorption with the free oligosaccharide chain. This result, together with the knowledge that these antibodies recognize several glycoconjugates, supports the conviction that these antibodies are non-specific for a gangliosidic structure.

Original languageEnglish
Pages (from-to)729-731
Number of pages3
JournalGlycoconjugate Journal
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 1995

Keywords

  • antibodies
  • membrane glycoconjugates
  • neuropathy

ASJC Scopus subject areas

  • Biochemistry

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