The Anti-Parasitic Effects of Nitric Oxide

Paolo Ascenzi, Alessio Bocedi, Luigi Gradoni

Research output: Contribution to journalArticlepeer-review

Abstract

Endogenous and exogenous nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa. However, NO production requires a tight control to limit cytotoxic damage to the host's own cells. The best known parasitic macromolecular targets for NO(-donors) are cysteine proteases, which are relevant in several aspects of the parasite life cycle and parasite-host relationships, and appear as promising targets for anti-parasitic chemotherapy.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalIUBMB Life
Volume55
Issue number10-11
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Anti-parasitic effects of NO(-donors)
  • Enzyme inhibition
  • Nitric oxide
  • NO-donors
  • Parasitic cysteine protease

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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