Hyperkeratosis of the follicular channel is the most common finding in acneic skin. The hyperkeratosis may represent an alterated keratinization process or the consequence of the abnormal sebum production and excretion. Several review demonstrated the anticomedonic activity of azelaic acid in acneic skin. This action may be due either to an antihormonal effect or to a change in keratine production. The aim of this work is to investigate the anticomedonic activity of 20% azelaic acid cream topically applied in a group of teen-agers affected by acne. A horny layer biopsy with cyanacrylate glue was performed before and after four months of treatment with azelaic acid cream in ten acneic patients. About 1 cm square horny layer biopsy was metallized and observed at the scanning electron microscopy to count the number of comedos. With this method we detected a reduction of about 26% of the comedos after four months of azelaic acid treatment. The result we obtained is in accordance with previous works about about the anticomedonic activity of azelaic acid.
|Translated title of the contribution||The anticomedonic activity of azelaic acid cream investigated by scanning electron microscopy on horny layer biopsy|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1990|
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