The anticonvulsant activity of γ-vinil-GABA and other GABA mimetics on kindling in rats

S. Assenza, M. G. Buzzi, F. De Romanis

Research output: Contribution to journalArticle

Abstract

Epileptic seizures following amygdala stimulation have been considered as an experimental model of local temporal seizures. We describe hereby the effects of different drugs which are commonly used in epilepsia treatment (phenobarbital, sodium valproate, progabide) and the effects of GABA agonists γ-vinyl-GABA and TIIIP on the severity of seizures and the duration of the afterdischarge period induced by amygdala stimulation. Drug and placebo animals were compared. All the tested drugs were effective in reducing seizure severity and afterdischarge period duration, thus confirming an involvement of GABA in amygdala stimulation-induced epileptic seizures.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalNew Trends in Clinical Neuropharmacology
Volume7
Issue number1-2
Publication statusPublished - 1993

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Amygdala
Anticonvulsants
gamma-Aminobutyric Acid
Seizures
Epilepsy
Pharmaceutical Preparations
GABA Agonists
Valproic Acid
Phenobarbital
Theoretical Models
Placebos
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology

Cite this

The anticonvulsant activity of γ-vinil-GABA and other GABA mimetics on kindling in rats. / Assenza, S.; Buzzi, M. G.; De Romanis, F.

In: New Trends in Clinical Neuropharmacology, Vol. 7, No. 1-2, 1993, p. 7-11.

Research output: Contribution to journalArticle

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