The anticytokine neuropeptide a-melanocyte-stimulating hormone in synovial fluid of patients with rheumatic diseases: Comparisons with other anticytokine molecules

Anna Catania, Valeria Gerloni, Samuele Procaccia, Lorena Airaghi, Maria G. Manfredi, Claudia Lomater, Luca Grossi, James M. Lipton

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to determine if the anticytokine neuropeptide α- melanocyte-stimulating hormone (a-MSH) occurs, along with interleukin 1 receptor antagonist (IL-lra) and soluble tumor necrosis factor receptor (sTNFr), in synovial fluid of patients with rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), or osteoarthritis. The data show that α-MSH does occur in the synovial fluid and its concentrations are greater in patients with RA than in those with osteoarthritis. Synovial fluid concentrations of IL-lra and sTNFr were likewise greater in RA. Further, concentrations of α-MSH, IL-l-ra, and sTNFr were greater in patients with polyarticular/systemic-onset JCA than in those with pauciarticular disease, that is in patients with greater joint inflammation. Concentrations of α-MSH were greater in synovial fluid than in plasma in a substantial proportion of patients, suggesting local production of the peptide; this is the first indication that the anticytokine molecule a-MSH is produced within a site of inflammation. Further, it appears that local production of α-MSH is induced particularly in those arthritic joints that have more intense inflammatory reactions. This finding, combined with previous evidence of the marked anti-inflammatory activity of α-MSH, suggests that the peptide acts locally to modulate proinflammatory influences in rheumatic diseases.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalNeuroImmunoModulation
Volume1
Issue number5
DOIs
Publication statusPublished - 1994

Keywords

  • Arthritis, juvenile chronic
  • Interleukin-1 receptor antagonist
  • Rheumatoid arthritis
  • Tumor necrosis factor receptor, soluble
  • α-Melanocyte stimulating hormone

ASJC Scopus subject areas

  • Endocrinology
  • Immunology
  • Endocrine and Autonomic Systems
  • Neurology
  • Neuroscience(all)

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