The antitumoral activity of some derivatives of 6-aminochrysene

H. J. Tagnon, André Coune, Sylvio Garattini, R. Rosso, G. Lambelin, M. Gautier, N. P. Buu-Hoï

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Abstract

Twenty-two N-substituted derivatives of the carcinostatic 6-aminochrysene have been tested as potential carcinostatic agents (using 6-aminochrysene as a standard) on spontaneous mammary tumor in [C3H/020] F1 mice, and on the slow-growing transplanted rhabdomyosarcoma in inbred WAG/Rij rats. Many of these compounds displayed important activity against both types of tumor, and some of them merit further investigations. In contrast compounds active on these experimental tumors, were completely inactive on Ehrlich carcinoma and on Sarcoma 180.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalEuropean Journal of Cancer (1965)
Volume6
Issue number2
DOIs
Publication statusPublished - 1970

ASJC Scopus subject areas

  • Medicine(all)

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    Tagnon, H. J., Coune, A., Garattini, S., Rosso, R., Lambelin, G., Gautier, M., & Buu-Hoï, N. P. (1970). The antitumoral activity of some derivatives of 6-aminochrysene. European Journal of Cancer (1965), 6(2), 81-87. https://doi.org/10.1016/0014-2964(70)90005-8