The apelin/APJ system: From vascular biology to heart failure

Pietro Francia, Cristina Balla, Francesco Paneni, Massimo Volpe

Research output: Contribution to journalArticlepeer-review


Apelin, the endogenous ligand of the G protein-coupled APJ receptor, displays several activities on the cardiovascular system. Indeed, recent studies support the notion that the apelin/APJ system is involved in key mechanisms that are relevant to fluid homeostasis, blood pressure control and cardiac contractility. This paper reviews our current knowledge on the physiological properties and potential clinical significance of apelin and APJ receptor.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalHigh Blood Pressure and Cardiovascular Prevention
Issue number4
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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