Apelin, the endogenous ligand of the G protein-coupled APJ receptor, displays several activities on the cardiovascular system. Indeed, recent studies support the notion that the apelin/APJ system is involved in key mechanisms that are relevant to fluid homeostasis, blood pressure control and cardiac contractility. This paper reviews our current knowledge on the physiological properties and potential clinical significance of apelin and APJ receptor.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine