The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea

F. I I Cosentino, Paolo Bosco, Valeria Drago, Giuseppina Prestianni, Bartolo Lanuzza, Ivan Iero, Mariangela Tripodi, Rosario S. Spada, Giuseppe Toscano, Filippo Caraci, Raffaele Ferri

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Contradictory data have been published on the influence of Apolipoprotein E (APOE) ε4 allele on obstructive sleep apnea (OSA). The aims of this study were to confirm the presence of specific neuropsychological changes in OSA patients carrying the APOE ε4 allele and to clarify if these changes are due to the sole presence of this allele or to its interactions with OSA pathology. Methods: The APOE genotype was examined in 123 patients with OSA and in 121 controls, together with a series of neuropsychological tests. Results: OSA and control subjects had similar APOE genotype and allele distribution, but when neuropsychological tests were considered, OSA patients showed significantly lower values for verbal long-term (delayed free recall at the Rey auditory-verbal learning test) and working memory (bisyllabic words). Moreover, spatial span was found to be lower in OSA ε4 allele carriers than in non-carriers; this difference was not observed in controls. Conclusions: This study confirms the presence of a verbal memory impairment in OSA patients and provides evidence for a significant interaction of APOE ε4 allele and OSA on frontal lobe function in adults, possibly mediated by the presence of specific frontal lobe neuroanatomical changes in these patients.

Original languageEnglish
Pages (from-to)831-839
Number of pages9
JournalSleep Medicine
Volume9
Issue number8
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Apolipoprotein E4
Obstructive Sleep Apnea
Short-Term Memory
Alleles
Neuropsychological Tests
Frontal Lobe
Apolipoproteins E
Genotype
Spatial Memory
Verbal Learning
Pathology

Keywords

  • ε4 allele
  • Apolipoprotein E
  • Frontal lobe functions
  • Neuropsychological tests
  • Obstructive sleep apnea
  • Spatial working memory

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea. / Cosentino, F. I I; Bosco, Paolo; Drago, Valeria; Prestianni, Giuseppina; Lanuzza, Bartolo; Iero, Ivan; Tripodi, Mariangela; Spada, Rosario S.; Toscano, Giuseppe; Caraci, Filippo; Ferri, Raffaele.

In: Sleep Medicine, Vol. 9, No. 8, 12.2008, p. 831-839.

Research output: Contribution to journalArticle

@article{42bdcaf92f7a4174bcab6780c41fd879,
title = "The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea",
abstract = "Background: Contradictory data have been published on the influence of Apolipoprotein E (APOE) ε4 allele on obstructive sleep apnea (OSA). The aims of this study were to confirm the presence of specific neuropsychological changes in OSA patients carrying the APOE ε4 allele and to clarify if these changes are due to the sole presence of this allele or to its interactions with OSA pathology. Methods: The APOE genotype was examined in 123 patients with OSA and in 121 controls, together with a series of neuropsychological tests. Results: OSA and control subjects had similar APOE genotype and allele distribution, but when neuropsychological tests were considered, OSA patients showed significantly lower values for verbal long-term (delayed free recall at the Rey auditory-verbal learning test) and working memory (bisyllabic words). Moreover, spatial span was found to be lower in OSA ε4 allele carriers than in non-carriers; this difference was not observed in controls. Conclusions: This study confirms the presence of a verbal memory impairment in OSA patients and provides evidence for a significant interaction of APOE ε4 allele and OSA on frontal lobe function in adults, possibly mediated by the presence of specific frontal lobe neuroanatomical changes in these patients.",
keywords = "ε4 allele, Apolipoprotein E, Frontal lobe functions, Neuropsychological tests, Obstructive sleep apnea, Spatial working memory",
author = "Cosentino, {F. I I} and Paolo Bosco and Valeria Drago and Giuseppina Prestianni and Bartolo Lanuzza and Ivan Iero and Mariangela Tripodi and Spada, {Rosario S.} and Giuseppe Toscano and Filippo Caraci and Raffaele Ferri",
year = "2008",
month = "12",
doi = "10.1016/j.sleep.2007.10.015",
language = "English",
volume = "9",
pages = "831--839",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier",
number = "8",

}

TY - JOUR

T1 - The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea

AU - Cosentino, F. I I

AU - Bosco, Paolo

AU - Drago, Valeria

AU - Prestianni, Giuseppina

AU - Lanuzza, Bartolo

AU - Iero, Ivan

AU - Tripodi, Mariangela

AU - Spada, Rosario S.

AU - Toscano, Giuseppe

AU - Caraci, Filippo

AU - Ferri, Raffaele

PY - 2008/12

Y1 - 2008/12

N2 - Background: Contradictory data have been published on the influence of Apolipoprotein E (APOE) ε4 allele on obstructive sleep apnea (OSA). The aims of this study were to confirm the presence of specific neuropsychological changes in OSA patients carrying the APOE ε4 allele and to clarify if these changes are due to the sole presence of this allele or to its interactions with OSA pathology. Methods: The APOE genotype was examined in 123 patients with OSA and in 121 controls, together with a series of neuropsychological tests. Results: OSA and control subjects had similar APOE genotype and allele distribution, but when neuropsychological tests were considered, OSA patients showed significantly lower values for verbal long-term (delayed free recall at the Rey auditory-verbal learning test) and working memory (bisyllabic words). Moreover, spatial span was found to be lower in OSA ε4 allele carriers than in non-carriers; this difference was not observed in controls. Conclusions: This study confirms the presence of a verbal memory impairment in OSA patients and provides evidence for a significant interaction of APOE ε4 allele and OSA on frontal lobe function in adults, possibly mediated by the presence of specific frontal lobe neuroanatomical changes in these patients.

AB - Background: Contradictory data have been published on the influence of Apolipoprotein E (APOE) ε4 allele on obstructive sleep apnea (OSA). The aims of this study were to confirm the presence of specific neuropsychological changes in OSA patients carrying the APOE ε4 allele and to clarify if these changes are due to the sole presence of this allele or to its interactions with OSA pathology. Methods: The APOE genotype was examined in 123 patients with OSA and in 121 controls, together with a series of neuropsychological tests. Results: OSA and control subjects had similar APOE genotype and allele distribution, but when neuropsychological tests were considered, OSA patients showed significantly lower values for verbal long-term (delayed free recall at the Rey auditory-verbal learning test) and working memory (bisyllabic words). Moreover, spatial span was found to be lower in OSA ε4 allele carriers than in non-carriers; this difference was not observed in controls. Conclusions: This study confirms the presence of a verbal memory impairment in OSA patients and provides evidence for a significant interaction of APOE ε4 allele and OSA on frontal lobe function in adults, possibly mediated by the presence of specific frontal lobe neuroanatomical changes in these patients.

KW - ε4 allele

KW - Apolipoprotein E

KW - Frontal lobe functions

KW - Neuropsychological tests

KW - Obstructive sleep apnea

KW - Spatial working memory

UR - http://www.scopus.com/inward/record.url?scp=55549144757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55549144757&partnerID=8YFLogxK

U2 - 10.1016/j.sleep.2007.10.015

DO - 10.1016/j.sleep.2007.10.015

M3 - Article

C2 - 18083630

AN - SCOPUS:55549144757

VL - 9

SP - 831

EP - 839

JO - Sleep Medicine

JF - Sleep Medicine

SN - 1389-9457

IS - 8

ER -