The Apolipoprotein E genotype in patients affected by syndromes with focal cortical atrophy

Carlo Masullo, Antonio Daniele, Vito M. Fazio, Davide Seripa, C. Gravina, Valeria Filippini, Dario Grossi, Nunzia Fragassi, Paolo Nichelli, Maria Leone, Guido Gainotti

Research output: Contribution to journalArticle

Abstract

The role of the Apolipoprotein E (APOE) alleles in syndromes associated with focal cerebral atrophy (fronto-temporal dementia, primary progressive aphasia, corticobasal degeneration) is still controversial. We studied the APOE allele distribution in 39 patients with clinically diagnosed syndromes associated with focal cerebral atrophy (FCA), in 50 patients with early-onset probable Alzheimer's disease (EOAD), and in 60 patients with late-onset probable AD (LOAD). The APOE genotype was determined from a blood sample, using polymerase chain reaction and restriction enzyme digestion. The APOE ε4 allele frequency was significantly higher in the EOAD (21.0%) and LOAD (33.3%) groups, but not in the FCA group (5.1%), as compared with controls. In our population, the ε2 allele frequency was significantly higher in patients with FCA (12.8%) than in controls (4.8%). These results show that the APOE ε4 allele is not a risk factor for syndromes associated with FCA. The potential role of the ε2 allele in these syndromes needs further investigation.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Volume303
Issue number2
DOIs
Publication statusPublished - May 4 2001

Keywords

  • Alzheimer's disease
  • Apolipoprotein E genotype
  • Corticobasal degeneration
  • Focal cortical atrophy
  • Fronto-temporal dementia
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Neuroscience(all)

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    Masullo, C., Daniele, A., Fazio, V. M., Seripa, D., Gravina, C., Filippini, V., Grossi, D., Fragassi, N., Nichelli, P., Leone, M., & Gainotti, G. (2001). The Apolipoprotein E genotype in patients affected by syndromes with focal cortical atrophy. Neuroscience Letters, 303(2), 87-90. https://doi.org/10.1016/S0304-3940(01)01673-1