The apoptosome: Emerging insights and new potential targets for drug design

Marcello D'Amelio, Elisa Tino, Francesco Cecconi

Research output: Contribution to journalArticlepeer-review

Abstract

Apoptosis plays a crucial role in tissue homeostasis, development and many diseases. The relevance of Apaf1, the molecular core of apoptosome, has been underlined in mitochondria-dependent apoptosis, which according to a growing body of evidence, is involved in various pathologies where the equilibrium of life-and-death is dysregulated, such as heart attack, stroke, liver failure, cancer and autoimmune diseases. Consequently, great interest has emerged in devising therapeutic strategies for regulating the key molecules involved in the life-and-death decision. Here we review recent progress in apoptosis-based pharmacological therapies and, in particular, we point out a possible role of the apoptosome as an emerging and promising pharmacological target.

Original languageEnglish
Pages (from-to)740-751
Number of pages12
JournalPharmaceutical Research
Volume25
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Apoptosis and disease
  • Apoptosis induction
  • Apoptosis inhibition
  • Apoptosome regulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmaceutical Science
  • Pharmacology

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