Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica.

Translated title of the contribution: The arrhythmogenicity of alpha 1-adrenergic stimulation following myocardial acidosis

G. Gambassi, P. Carbonin, M. C. Capogrossi

Research output: Contribution to journalArticle

Abstract

Ischemia is associated with myocardial acidosis which recovers upon reperfusion. In such conditions, alpha 1-adrenergic stimulation is arrhythmogenic. We used single cardiac myocytes loaded with the pH fluorescent dye, SNARF-1, to determine if a modulation of pH could explain the effect of alpha 1-adrenergic stimulation. Cells were exposed to acidosis (CO2 15%) for 15 min and then normocapnia restored. During acidosis, alpha 1-adrenergic stimulation caused an increase in pH which was abolished by blocking Na+/H+ exchange with ethylisopropylamiloride (EIPA). After removal of acidosis aftercontractions were manifest in 8 out of 10 and 1 out of 5 cells in the presence of an alpha 1-adrenergic agonist and in control, respectively (p <0.001). EIPA abolished the occurrence of after contractions. Thus, the arrhythmogenicity of alpha 1-adrenergic stimulation depends on activation of Na+/H+ exchanger.

Original languageItalian
Pages (from-to)569-571
Number of pages3
JournalCardiologia
Volume37
Issue number8
Publication statusPublished - Aug 1992

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Acidosis
Adrenergic Agents
Adrenergic alpha-1 Receptor Agonists
Sodium-Hydrogen Antiporter
Fluorescent Dyes
Cardiac Myocytes
Reperfusion
Ischemia
ethylisopropylamiloride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gambassi, G., Carbonin, P., & Capogrossi, M. C. (1992). Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica. Cardiologia, 37(8), 569-571.

Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica. / Gambassi, G.; Carbonin, P.; Capogrossi, M. C.

In: Cardiologia, Vol. 37, No. 8, 08.1992, p. 569-571.

Research output: Contribution to journalArticle

Gambassi, G, Carbonin, P & Capogrossi, MC 1992, 'Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica.', Cardiologia, vol. 37, no. 8, pp. 569-571.
Gambassi G, Carbonin P, Capogrossi MC. Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica. Cardiologia. 1992 Aug;37(8):569-571.
Gambassi, G. ; Carbonin, P. ; Capogrossi, M. C. / Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica. In: Cardiologia. 1992 ; Vol. 37, No. 8. pp. 569-571.
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