Aritmogenicità della stimolazione alpha 1-adrenergica dopo acidosi miocardica.

Translated title of the contribution: The arrhythmogenicity of alpha 1-adrenergic stimulation following myocardial acidosis

G. Gambassi, P. Carbonin, M. C. Capogrossi

Research output: Contribution to journalArticlepeer-review

Abstract

Ischemia is associated with myocardial acidosis which recovers upon reperfusion. In such conditions, alpha 1-adrenergic stimulation is arrhythmogenic. We used single cardiac myocytes loaded with the pH fluorescent dye, SNARF-1, to determine if a modulation of pH could explain the effect of alpha 1-adrenergic stimulation. Cells were exposed to acidosis (CO2 15%) for 15 min and then normocapnia restored. During acidosis, alpha 1-adrenergic stimulation caused an increase in pH which was abolished by blocking Na+/H+ exchange with ethylisopropylamiloride (EIPA). After removal of acidosis aftercontractions were manifest in 8 out of 10 and 1 out of 5 cells in the presence of an alpha 1-adrenergic agonist and in control, respectively (p <0.001). EIPA abolished the occurrence of after contractions. Thus, the arrhythmogenicity of alpha 1-adrenergic stimulation depends on activation of Na+/H+ exchanger.

Translated title of the contributionThe arrhythmogenicity of alpha 1-adrenergic stimulation following myocardial acidosis
Original languageItalian
Pages (from-to)569-571
Number of pages3
JournalCardiologia
Volume37
Issue number8
Publication statusPublished - Aug 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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