The association between 24-h blood pressure patterns and left ventricular mechanics

Marijana Tadic, Cesare Cuspidi, Anka Majstorovic, Biljana Pencic, Giuseppe Mancia, Michele Bombelli, Guido Grassi, Vesna Kocijancic, Vladimir Djukic, Vera Celic

Research output: Contribution to journalArticlepeer-review

Abstract

Objective:We sought to investigate left ventricular (LV) mechanics in the recently diagnosed hypertensive patients with different 24-h blood pressure (BP) patterns (dipping, nondipping, extreme dipping and reverse dipping).Methods:The current cross-sectional study included 209 hypertensive patients who underwent 24-h ambulatory BP monitoring and comprehensive two-dimensional echocardiographic examination including multilayer strain analysis.Results:There was no difference in 24-h and daytime BP values between four groups. Night-time BP significantly and gradually increased from extreme dippers, across dippers and nondippers, to reverse dippers. LV global longitudinal and circumferential strains were greater in dippers and extreme dippers than in nondippers and reverse dippers. This was also found for endocardial and epicardial LV longitudinal and circumferential strains. Multivariate logistic regression analysis demonstrated that nondipping and reverse dipping patterns were associated with reduced LV longitudinal strain [odds ratio (OR) 1.71 (95% confidence interval (CI): 1.10-5.61) and OR 2.50 (95% CI: 1.31-6.82), respectively] independently of age, sex, 24-h SBP, LV mass index and E/è. Only the reverse dipping BP pattern was independently of clinical and echocardiographic parameters related with reduced LV circumferential strain [OR 1.90 (95% CI: 1.10-4.80)].Conclusion:Nondipping and reverse dipping BP patterns had stronger impact on LV mechanics compared with patients with dipping and extreme dipping BP patterns in hypertensive population. LV functional and mechanical remodeling deteriorated from extreme dippers and dippers, to nondippers and reverse dippers.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalJournal of Hypertension
Volume38
Issue number2
DOIs
Publication statusPublished - Feb 1 2020

Keywords

  • extreme dipping
  • hypertension
  • left ventricle
  • nondipping
  • reverse dipping
  • strain

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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