The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women

Dayna S. Early, Feng Gao, Christina Y. Ha, Anne Nagler, Elizabeth Cole, Elizabeth Gorbe, Nicola Napoli, Reina Armamento-Villareal

Research output: Contribution to journalArticle

Abstract

Background The impact of estrogen on risk of colorectal neoplasia is uncertain. Carriers of the AA and CA genotype allele of the C4887A polymorphism of the CYP1A1 gene have enhanced estrogen metabolism relative to carriers of the CC genotype. Aims This study examined whether this genetic marker of enhanced estrogen catabolism segregated with colorectal neoplasia (CRN) in postmenopausal women. Methods We enrolled hormone negative postmenopausal women having screening or surveillance colonoscopy. Demographic and medical data were gathered. Blood was collected and analyzed for CYP1A1 polymorphisms of the C4887A allele by PCR-RFLP. Colonoscopy and pathology data were gathered from hospital databases. Results One hundred sixty-eight women were enrolled in the study. Twenty-one subjects (12.5%) carried at least one A allele, and 147 subjects (87.5%) carried the CC alleles for the C4887A polymorphism of the CYP1A1 gene. Seventy subjects (41.7%) had CRN and 98 subjects (58.3%) did not have CRN. Of the subjects who carried the A allele, 57% had CRN as compared to 39% of those who carried the CC allele; the association was not statistically significant (P = 0.16). In a multivariate logistic regression analysis, age, BMI, current tobacco use, and first degree relative with CRN were independent risk factors for CRN but the C4887A polymorphisms remained not statistically significant (P = 0.35). Conclusions Carriers of the A allele of the C4887A polymorphism have enhanced estrogen catabolism and lower free estradiol. Our results suggest, however, that inherent estrogen metabolism as determined by C4887A polymorphisms is not associated with CRN risk.

Original languageEnglish
Pages (from-to)2965-2970
Number of pages6
JournalDigestive Diseases and Sciences
Volume55
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Cytochrome P-450 CYP1A1
Alleles
Estrogens
Neoplasms
Colonoscopy
Genotype
Tobacco Use
Genetic Markers
Restriction Fragment Length Polymorphisms
Genes
Estradiol
Logistic Models
Regression Analysis
Demography
Databases
Hormones
Pathology
Polymerase Chain Reaction

Keywords

  • Colorectal neoplasia
  • CYP polymorphisms
  • Estrogen
  • Postmenopausal
  • Screening

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Early, D. S., Gao, F., Ha, C. Y., Nagler, A., Cole, E., Gorbe, E., ... Armamento-Villareal, R. (2010). The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women. Digestive Diseases and Sciences, 55(10), 2965-2970. https://doi.org/10.1007/s10620-009-1105-9

The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women. / Early, Dayna S.; Gao, Feng; Ha, Christina Y.; Nagler, Anne; Cole, Elizabeth; Gorbe, Elizabeth; Napoli, Nicola; Armamento-Villareal, Reina.

In: Digestive Diseases and Sciences, Vol. 55, No. 10, 10.2010, p. 2965-2970.

Research output: Contribution to journalArticle

Early, DS, Gao, F, Ha, CY, Nagler, A, Cole, E, Gorbe, E, Napoli, N & Armamento-Villareal, R 2010, 'The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women', Digestive Diseases and Sciences, vol. 55, no. 10, pp. 2965-2970. https://doi.org/10.1007/s10620-009-1105-9
Early, Dayna S. ; Gao, Feng ; Ha, Christina Y. ; Nagler, Anne ; Cole, Elizabeth ; Gorbe, Elizabeth ; Napoli, Nicola ; Armamento-Villareal, Reina. / The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women. In: Digestive Diseases and Sciences. 2010 ; Vol. 55, No. 10. pp. 2965-2970.
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abstract = "Background The impact of estrogen on risk of colorectal neoplasia is uncertain. Carriers of the AA and CA genotype allele of the C4887A polymorphism of the CYP1A1 gene have enhanced estrogen metabolism relative to carriers of the CC genotype. Aims This study examined whether this genetic marker of enhanced estrogen catabolism segregated with colorectal neoplasia (CRN) in postmenopausal women. Methods We enrolled hormone negative postmenopausal women having screening or surveillance colonoscopy. Demographic and medical data were gathered. Blood was collected and analyzed for CYP1A1 polymorphisms of the C4887A allele by PCR-RFLP. Colonoscopy and pathology data were gathered from hospital databases. Results One hundred sixty-eight women were enrolled in the study. Twenty-one subjects (12.5{\%}) carried at least one A allele, and 147 subjects (87.5{\%}) carried the CC alleles for the C4887A polymorphism of the CYP1A1 gene. Seventy subjects (41.7{\%}) had CRN and 98 subjects (58.3{\%}) did not have CRN. Of the subjects who carried the A allele, 57{\%} had CRN as compared to 39{\%} of those who carried the CC allele; the association was not statistically significant (P = 0.16). In a multivariate logistic regression analysis, age, BMI, current tobacco use, and first degree relative with CRN were independent risk factors for CRN but the C4887A polymorphisms remained not statistically significant (P = 0.35). Conclusions Carriers of the A allele of the C4887A polymorphism have enhanced estrogen catabolism and lower free estradiol. Our results suggest, however, that inherent estrogen metabolism as determined by C4887A polymorphisms is not associated with CRN risk.",
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AU - Cole, Elizabeth

AU - Gorbe, Elizabeth

AU - Napoli, Nicola

AU - Armamento-Villareal, Reina

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N2 - Background The impact of estrogen on risk of colorectal neoplasia is uncertain. Carriers of the AA and CA genotype allele of the C4887A polymorphism of the CYP1A1 gene have enhanced estrogen metabolism relative to carriers of the CC genotype. Aims This study examined whether this genetic marker of enhanced estrogen catabolism segregated with colorectal neoplasia (CRN) in postmenopausal women. Methods We enrolled hormone negative postmenopausal women having screening or surveillance colonoscopy. Demographic and medical data were gathered. Blood was collected and analyzed for CYP1A1 polymorphisms of the C4887A allele by PCR-RFLP. Colonoscopy and pathology data were gathered from hospital databases. Results One hundred sixty-eight women were enrolled in the study. Twenty-one subjects (12.5%) carried at least one A allele, and 147 subjects (87.5%) carried the CC alleles for the C4887A polymorphism of the CYP1A1 gene. Seventy subjects (41.7%) had CRN and 98 subjects (58.3%) did not have CRN. Of the subjects who carried the A allele, 57% had CRN as compared to 39% of those who carried the CC allele; the association was not statistically significant (P = 0.16). In a multivariate logistic regression analysis, age, BMI, current tobacco use, and first degree relative with CRN were independent risk factors for CRN but the C4887A polymorphisms remained not statistically significant (P = 0.35). Conclusions Carriers of the A allele of the C4887A polymorphism have enhanced estrogen catabolism and lower free estradiol. Our results suggest, however, that inherent estrogen metabolism as determined by C4887A polymorphisms is not associated with CRN risk.

AB - Background The impact of estrogen on risk of colorectal neoplasia is uncertain. Carriers of the AA and CA genotype allele of the C4887A polymorphism of the CYP1A1 gene have enhanced estrogen metabolism relative to carriers of the CC genotype. Aims This study examined whether this genetic marker of enhanced estrogen catabolism segregated with colorectal neoplasia (CRN) in postmenopausal women. Methods We enrolled hormone negative postmenopausal women having screening or surveillance colonoscopy. Demographic and medical data were gathered. Blood was collected and analyzed for CYP1A1 polymorphisms of the C4887A allele by PCR-RFLP. Colonoscopy and pathology data were gathered from hospital databases. Results One hundred sixty-eight women were enrolled in the study. Twenty-one subjects (12.5%) carried at least one A allele, and 147 subjects (87.5%) carried the CC alleles for the C4887A polymorphism of the CYP1A1 gene. Seventy subjects (41.7%) had CRN and 98 subjects (58.3%) did not have CRN. Of the subjects who carried the A allele, 57% had CRN as compared to 39% of those who carried the CC allele; the association was not statistically significant (P = 0.16). In a multivariate logistic regression analysis, age, BMI, current tobacco use, and first degree relative with CRN were independent risk factors for CRN but the C4887A polymorphisms remained not statistically significant (P = 0.35). Conclusions Carriers of the A allele of the C4887A polymorphism have enhanced estrogen catabolism and lower free estradiol. Our results suggest, however, that inherent estrogen metabolism as determined by C4887A polymorphisms is not associated with CRN risk.

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