The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA study

Angelique P A Vermeiren, Hans Bosma, Pieter Jelle Visser, Maurice P. Zeegers, Caroline Graff, Michael Ewers, Giovanni B. Frisoni, Lutz Frölich, Harald Hampel, Roy W. Jones, Patrick G. Kehoe, Hermine Lenoir, Lennart Minthon, Flavio M. Nobili, Marcel Olde Rikkert, Anne Sophie Rigaud, Philip Scheltens, Hilkka Soininen, Luiza Spiru, Magda TsolakiLars Olof Wahlund, Bruno Vellas, Gordon Wilcock, Lyzel S. Elias-Sonnenschein, Frans R J Verhey

Research output: Contribution to journalArticle

Abstract

We assessed the interaction between the APOE ε4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE ε4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalJournal of Alzheimer's Disease
Volume35
Issue number2
DOIs
Publication statusPublished - 2013

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Keywords

  • APOE ε4
  • cohort study
  • dementia
  • education
  • mild cognitive impairment
  • multicenter study
  • socio-economic status

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Vermeiren, A. P. A., Bosma, H., Visser, P. J., Zeegers, M. P., Graff, C., Ewers, M., Frisoni, G. B., Frölich, L., Hampel, H., Jones, R. W., Kehoe, P. G., Lenoir, H., Minthon, L., Nobili, F. M., Olde Rikkert, M., Rigaud, A. S., Scheltens, P., Soininen, H., Spiru, L., ... Verhey, F. R. J. (2013). The association between APOE ε4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education. The DESCRIPA study. Journal of Alzheimer's Disease, 35(2), 241-246. https://doi.org/10.3233/JAD-122182