The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European prospective investigation into cancer and nutrition

Francesca L. Crowe, Timothy J. Key, Naomi E. Allen, Paul N. Appleby, Andrew Roddam, Kim Overvad, Henning Grønbæk, Anne Tjønneland, Jutte Halkjær, Laure Dossus, Heiner Boeing, Janine Kröger, Antonia Trichopoulou, Vardis Dilis, Dimitrios Trichopoulos, Marie Christine Boutron-Ruault, Blandine De Lauzon, Françoise Clavel-Chapelon, Domenico Palli, Franco BerrinoSalvatore Panico, Rosario Tumino, Carlotta Sacerdote, H. Bas Bueno-de-Mesquita, Alina Vrieling, Carla H. Van Gils, Petra H M Peeters, Inger T. Gram, Guri Skeie, Eiliv Lund, Laudina Rodríguez, Paula Jakszyn, Esther Molina-Montes, María J. Tormo, Aurelio Barricarte, Nerea Larrañaga, Kay Tee Khaw, Sheila Bingham, Sabina Rinaldi, Nadia Slimani, Teresa Norat, Valentina Gallo, Elio Riboli, Rudolf Kaaks

Research output: Contribution to journalArticlepeer-review

Abstract

Circulating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in a cross-sectional analysis of 4,731 men and women taking part in the European Prospective Investigation into Cancer and Nutrition. Diet was assessed using country-specific validated dietary questionnaires. Serum concentrations of IGF-I, IGFBP-1, IGFBP-2 and IGFBP-3 were measured, and the associations between diet and IGF-I and IGFBPs were assessed using multiple linear regression adjusting for sex, age, body mass index, smoking status, and alcohol and energy intake. Each 1 SD increment increase in total and dairy protein and calcium intake was associated with an increase in IGF-I concentration of 2.5%, 2.4%, and 3.3%, respectively (P for trend

Original languageEnglish
Pages (from-to)1333-1340
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number5
DOIs
Publication statusPublished - May 2009

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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