The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk

So Yeon Kong, Masayoshi Takeuchi, Hideyuki Hyogo, Gail McKeown-Eyssen, Sho Ichi Yamagishi, Kazuaki Chayama, Peter J. O'Brien, Pietro Ferrari, Kim Overvad, Anja Olsen, Anne Tjønneland, Marie Christine Boutron-Ruault, Nadia Bastide, Franck Carbonnel, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona LagiouEffie Vasilopoulou, Giovanna Masala, Valeria Pala, Maria Santucci De Magistris, Rosario Tumino, Alessio Naccarati, H. B. Bueno-De-Mesquita, Petra H. Peeters, Elisabete Weiderpass, J. Ramón Quiŕos, Paula Jakszyn, María Jos̈e ͆anchez, Miren Dorronsoro, Diana Gavrila, Eva Ardanaz, Martin Rutegård, Hanna Nyström, Nicholas J. Wareham, Kay Tee Khaw, Kathryn E. Bradbury, Isabelle Romieu, Heinz Freisling, Faidra Stavropoulou, Marc J. Gunter, Amanda J. Cross, Elio Riboli, Mazda Jenab, W. Robert Bruce

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehydederived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer. Methods: A total of 1, 055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1:1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status. Results: Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.57-1.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity= 0.14). Conclusions: In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact: Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development. Cancer Epidemiol Biomarkers Prev; 24(12); 1855-63.

Original languageEnglish
Pages (from-to)1855-1863
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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