TY - JOUR
T1 - The association between metabolic syndrome and restrictive ventilatory dysfunction in older persons
AU - Fimognari, Filippo Luca
AU - Pasqualetti, Patrizio
AU - Moro, Leo
AU - Franco, Alessandro
AU - Piccirillo, Gianfranco
AU - Pastorelli, Ruggero
AU - Rossini, Paolo Maria
AU - Incalzi, Raffaele Antonelli
PY - 2007/7
Y1 - 2007/7
N2 - Background. The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of metabolic syndrome and increased insulin resistance than were obstructive and normal respiratory patterns. Methods. We performed a cross-sectional study of 159 consecutive nondiabetic elderly persons attending two social centers. According to their spirometric pattern, volunteers were classified into the following categories: normal spirometry, obstructive (forced expiratory volume in 1 second/forced vital capacity <0.70), and restrictive pattern (forced vital capacity <80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70). Independent correlates of the metabolic syndrome were identified. Results. The prevalence of metabolic syndrome was higher in restrictive (56%) than in both normal (21.4%, p = .001) and obstructive volunteers (12.9%, p = .001). Insulin resistance, as assessed by the log transformation of the Homeostasis Model Assessment (HOMA), was higher in restrictive than in obstructive and normal volunteers (1 ± 0.6 vs 0.3 ± 0.6 and 0.5 ± 0.5, p <.001). Restriction was an independent correlate of metabolic syndrome, also after adjustment for waist circumference and body mass index (odds ratio = 3.23, 95% confidence interval, 1.23-8.48; p = .01). Conclusion. Restrictive, but not obstructive respiratory pattern, is associated with metabolic syndrome and insulin resistance, and does not only reflect a limitation of ventilation due to visceral obesity. Metabolic abnormalities likely mediate cardiovascular risk in patients with restrictive respiratory impairment.
AB - Background. The restrictive, but not the obstructive respiratory dysfunction, is associated with an increased risk of developing type 2 diabetes mellitus. Our aim was to verify in an elderly nondiabetic population whether a restrictive respiratory pattern was associated with a higher prevalence of metabolic syndrome and increased insulin resistance than were obstructive and normal respiratory patterns. Methods. We performed a cross-sectional study of 159 consecutive nondiabetic elderly persons attending two social centers. According to their spirometric pattern, volunteers were classified into the following categories: normal spirometry, obstructive (forced expiratory volume in 1 second/forced vital capacity <0.70), and restrictive pattern (forced vital capacity <80% predicted, forced expiratory volume in 1 second/forced vital capacity ≥ 0.70). Independent correlates of the metabolic syndrome were identified. Results. The prevalence of metabolic syndrome was higher in restrictive (56%) than in both normal (21.4%, p = .001) and obstructive volunteers (12.9%, p = .001). Insulin resistance, as assessed by the log transformation of the Homeostasis Model Assessment (HOMA), was higher in restrictive than in obstructive and normal volunteers (1 ± 0.6 vs 0.3 ± 0.6 and 0.5 ± 0.5, p <.001). Restriction was an independent correlate of metabolic syndrome, also after adjustment for waist circumference and body mass index (odds ratio = 3.23, 95% confidence interval, 1.23-8.48; p = .01). Conclusion. Restrictive, but not obstructive respiratory pattern, is associated with metabolic syndrome and insulin resistance, and does not only reflect a limitation of ventilation due to visceral obesity. Metabolic abnormalities likely mediate cardiovascular risk in patients with restrictive respiratory impairment.
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M3 - Article
C2 - 17634324
AN - SCOPUS:34548385683
VL - 62
SP - 760
EP - 765
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 7
ER -