The association of ageing with calcium active hormone status in men

G. Ravaglia, P. Forti, L. Pratelli, F. Maioli, C. R. Scali, A. M. Bonini, S. Tedioli, N. Marasti, A. Pizzoferrato, G. Gasbarrini

Research output: Contribution to journalArticlepeer-review

Abstract

We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalAge and Ageing
Volume23
Issue number2
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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