Abstract
We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.
| Original language | English |
|---|---|
| Pages (from-to) | 127-131 |
| Number of pages | 5 |
| Journal | Age and Ageing |
| Volume | 23 |
| Issue number | 2 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
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The association of ageing with calcium active hormone status in men. / Ravaglia, G.; Forti, P.; Pratelli, L.; Maioli, F.; Scali, C. R.; Bonini, A. M.; Tedioli, S.; Marasti, N.; Pizzoferrato, A.; Gasbarrini, G.
In: Age and Ageing, Vol. 23, No. 2, 1994, p. 127-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association of ageing with calcium active hormone status in men
AU - Ravaglia, G.
AU - Forti, P.
AU - Pratelli, L.
AU - Maioli, F.
AU - Scali, C. R.
AU - Bonini, A. M.
AU - Tedioli, S.
AU - Marasti, N.
AU - Pizzoferrato, A.
AU - Gasbarrini, G.
PY - 1994
Y1 - 1994
N2 - We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.
AB - We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028218193&partnerID=8YFLogxK
M3 - Article
C2 - 8023720
AN - SCOPUS:0028218193
VL - 23
SP - 127
EP - 131
JO - Age and Ageing
JF - Age and Ageing
SN - 0002-0729
IS - 2
ER -