The association of ageing with calcium active hormone status in men

G. Ravaglia; P. Forti; L. Pratelli; F. Maioli; C. R. Scali; A. M. Bonini; S. Tedioli; N. Marasti; A. Pizzoferrato; G. Gasbarrini

The association of ageing with calcium active hormone status in men

G. Ravaglia, P. Forti, L. Pratelli, F. Maioli, C. R. Scali, A. M. Bonini, S. Tedioli, N. Marasti, A. Pizzoferrato, G. Gasbarrini

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Age and Ageing
Volume	23
Issue number	2
Publication status	Published - 1994

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology

Cite this

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AU - Ravaglia, G.

AU - Forti, P.

AU - Pratelli, L.

AU - Maioli, F.

AU - Scali, C. R.

AU - Bonini, A. M.

AU - Tedioli, S.

AU - Marasti, N.

AU - Pizzoferrato, A.

AU - Gasbarrini, G.

PY - 1994

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AB - We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.

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The association of ageing with calcium active hormone status in men

Abstract

ASJC Scopus subject areas

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