The association of ageing with calcium active hormone status in men

G. Ravaglia; P. Forti; L. Pratelli; F. Maioli; C. R. Scali; A. M. Bonini; S. Tedioli; N. Marasti; A. Pizzoferrato; G. Gasbarrini

The association of ageing with calcium active hormone status in men

G. Ravaglia, P. Forti, L. Pratelli, F. Maioli, C. R. Scali, A. M. Bonini, S. Tedioli, N. Marasti, A. Pizzoferrato, G. Gasbarrini

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Age and Ageing
Volume	23
Issue number	2
Publication status	Published - 1994

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'The association of ageing with calcium active hormone status in men'. Together they form a unique fingerprint.

Cite this

@article{ab6dbe37d42448fbb85f63c2ff1638ba,

title = "The association of ageing with calcium active hormone status in men",

abstract = "We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.",

author = "G. Ravaglia and P. Forti and L. Pratelli and F. Maioli and Scali, {C. R.} and Bonini, {A. M.} and S. Tedioli and N. Marasti and A. Pizzoferrato and G. Gasbarrini",

year = "1994",

language = "English",

volume = "23",

pages = "127--131",

journal = "Age and Ageing",

issn = "0002-0729",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - The association of ageing with calcium active hormone status in men

AU - Ravaglia, G.

AU - Forti, P.

AU - Pratelli, L.

AU - Maioli, F.

AU - Scali, C. R.

AU - Bonini, A. M.

AU - Tedioli, S.

AU - Marasti, N.

AU - Pizzoferrato, A.

AU - Gasbarrini, G.

PY - 1994

Y1 - 1994

N2 - We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.

AB - We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24-88 years). Vitamin D (1,25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p <0.01) together with a parallel increase in urinary (r = 0.46, p <0.05) and nephrogenic cAMP (r = 0.63, p <0.01), while BMD decreases with age (r =0.52, p <0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1,25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly men.

UR - http://www.scopus.com/inward/record.url?scp=0028218193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028218193&partnerID=8YFLogxK

M3 - Article

C2 - 8023720

AN - SCOPUS:0028218193

VL - 23

SP - 127

EP - 131

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

IS - 2

ER -