Abstract
We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.
| Original language | English |
|---|---|
| Pages (from-to) | 456-463 |
| Number of pages | 8 |
| Journal | Calcified Tissue International |
| Volume | 89 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2011 |
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Keywords
- 25OHD
- Bone marker
- Fat mass
- Lean mass
- Quantitative ultrasound
- Sex hormone
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women. / Gonnelli, S.; Caffarelli, C.; Tanzilli, L.; Merlotti, D.; Gennari, L.; Rossi, S.; Lucani, B.; Campagna, M. S.; Franci, B.; Nuti, R.
In: Calcified Tissue International, Vol. 89, No. 6, 12.2011, p. 456-463.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women
AU - Gonnelli, S.
AU - Caffarelli, C.
AU - Tanzilli, L.
AU - Merlotti, D.
AU - Gennari, L.
AU - Rossi, S.
AU - Lucani, B.
AU - Campagna, M. S.
AU - Franci, B.
AU - Nuti, R.
PY - 2011/12
Y1 - 2011/12
N2 - We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.
AB - We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.
KW - 25OHD
KW - Bone marker
KW - Fat mass
KW - Lean mass
KW - Quantitative ultrasound
KW - Sex hormone
UR - http://www.scopus.com/inward/record.url?scp=82455209078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82455209078&partnerID=8YFLogxK
U2 - 10.1007/s00223-011-9534-9
DO - 10.1007/s00223-011-9534-9
M3 - Article
C2 - 21986718
AN - SCOPUS:82455209078
VL - 89
SP - 456
EP - 463
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 6
ER -