The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women

S. Gonnelli, C. Caffarelli, L. Tanzilli, D. Merlotti, L. Gennari, S. Rossi, B. Lucani, M. S. Campagna, B. Franci, R. Nuti

Research output: Contribution to journalArticle

Abstract

We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalCalcified Tissue International
Volume89
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Calcaneus
Gonadal Steroid Hormones
Body Composition
Bone and Bones
Fats
Alkaline Phosphatase
Estrogens
Sex Hormone-Binding Globulin
Bone Remodeling
Collagen Type I
Androgens
Testosterone
Estradiol
Serum

Keywords

  • 25OHD
  • Bone marker
  • Fat mass
  • Lean mass
  • Quantitative ultrasound
  • Sex hormone

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women. / Gonnelli, S.; Caffarelli, C.; Tanzilli, L.; Merlotti, D.; Gennari, L.; Rossi, S.; Lucani, B.; Campagna, M. S.; Franci, B.; Nuti, R.

In: Calcified Tissue International, Vol. 89, No. 6, 12.2011, p. 456-463.

Research output: Contribution to journalArticle

Gonnelli, S, Caffarelli, C, Tanzilli, L, Merlotti, D, Gennari, L, Rossi, S, Lucani, B, Campagna, MS, Franci, B & Nuti, R 2011, 'The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women', Calcified Tissue International, vol. 89, no. 6, pp. 456-463. https://doi.org/10.1007/s00223-011-9534-9
Gonnelli, S. ; Caffarelli, C. ; Tanzilli, L. ; Merlotti, D. ; Gennari, L. ; Rossi, S. ; Lucani, B. ; Campagna, M. S. ; Franci, B. ; Nuti, R. / The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women. In: Calcified Tissue International. 2011 ; Vol. 89, No. 6. pp. 456-463.
@article{41b10de105c64605aa5611e93c37581f,
title = "The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women",
abstract = "We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.",
keywords = "25OHD, Bone marker, Fat mass, Lean mass, Quantitative ultrasound, Sex hormone",
author = "S. Gonnelli and C. Caffarelli and L. Tanzilli and D. Merlotti and L. Gennari and S. Rossi and B. Lucani and Campagna, {M. S.} and B. Franci and R. Nuti",
year = "2011",
month = "12",
doi = "10.1007/s00223-011-9534-9",
language = "English",
volume = "89",
pages = "456--463",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - The Association of Body Composition and Sex Hormones with Quantitative Ultrasound Parameters at the Calcaneus and Phalanxes in Elderly Women

AU - Gonnelli, S.

AU - Caffarelli, C.

AU - Tanzilli, L.

AU - Merlotti, D.

AU - Gennari, L.

AU - Rossi, S.

AU - Lucani, B.

AU - Campagna, M. S.

AU - Franci, B.

AU - Nuti, R.

PY - 2011/12

Y1 - 2011/12

N2 - We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.

AB - We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E 2), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E 2 and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E 2 and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E 2 and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.

KW - 25OHD

KW - Bone marker

KW - Fat mass

KW - Lean mass

KW - Quantitative ultrasound

KW - Sex hormone

UR - http://www.scopus.com/inward/record.url?scp=82455209078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455209078&partnerID=8YFLogxK

U2 - 10.1007/s00223-011-9534-9

DO - 10.1007/s00223-011-9534-9

M3 - Article

C2 - 21986718

AN - SCOPUS:82455209078

VL - 89

SP - 456

EP - 463

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 6

ER -