The association of chemotherapy and radiotherapy in squamous cell carcinoma of anal canal

Francesca Valvo, Barbara Avuzzi, Federico Bozzetti

Research output: Contribution to journalArticlepeer-review

Abstract

Squamous cell carcinoma of anal canal (SCCA) and its precursor lesions are increasing in prevalence for the diffusion of human papillomavirus infection. The treatment of the cancer of the anal canal represents a model for the application of organ sparing, combined modality therapy for curative treatment. Squamous cell carcinoma of anal canal was originally a surgically treated disease that required Abdominoperineal Resection (APR), approximately two thirds of patients are now cured with a combination of chemotherapy and radiation with sphincter preservation. This article reviews randomized trials and recent studies on chemoradiation for anal cancer.

Original languageEnglish
Pages (from-to)220-228
Number of pages9
JournalCurrent Drug Therapy
Volume5
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • Anal cancer
  • Chemotherapy
  • Radiotherapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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