The association of chronic hepatitis B and myopathy

M. Capasso, A. Di Muzio, M. Comar, I. Robuffo, A. Gambi, S. Crovella, E. Pizzigallo, C. Campello, A. Uncini

Research output: Contribution to journalArticlepeer-review

Abstract

In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.

Original languageEnglish
Pages (from-to)1467-1469
Number of pages3
JournalNeurology
Volume67
Issue number8
DOIs
Publication statusPublished - Oct 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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