The association of chronic hepatitis B and myopathy

M. Capasso; A. Di Muzio; M. Comar; I. Robuffo; A. Gambi; S. Crovella; E. Pizzigallo; C. Campello; A. Uncini

doi:10.1212/01.wnl.0000240078.47020.5e

The association of chronic hepatitis B and myopathy

M. Capasso, A. Di Muzio, M. Comar, I. Robuffo, A. Gambi, S. Crovella, E. Pizzigallo, C. Campello, A. Uncini

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.

Original language	English
Pages (from-to)	1467-1469
Number of pages	3
Journal	Neurology
Volume	67
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000240078.47020.5e
Publication status	Published - Oct 2006

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.",

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AU - Capasso, M.

AU - Di Muzio, A.

AU - Comar, M.

AU - Robuffo, I.

AU - Gambi, A.

AU - Crovella, S.

AU - Pizzigallo, E.

AU - Campello, C.

AU - Uncini, A.

PY - 2006/10

Y1 - 2006/10

N2 - In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.

AB - In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.

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JO - Neurology

JF - Neurology

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ER -

The association of chronic hepatitis B and myopathy

Abstract

ASJC Scopus subject areas

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