The association of high-sensitivity c-reactive protein and other biomarkers with cardiovascular disease in patients treated for HIV: A nested case-control study

Andrea De Luca, Katleen de Gaetano Donati, Manuela Colafigli, Alessandro Cozzi-Lepri, Amalia De Curtis, Andrea Gori, Laura Sighinolfi, Andrea Giacometti, Maria Rosaria Capobianchi, Alessandro D'Avino, Licia Iacoviello, Roberto Cauda, Antonella D'Arminio Monforte

Research output: Contribution to journalArticle

Abstract

Background: Elevated high-sensitivity C-reactive protein (hsCRP) increases the risk of cardiovascular disease (CVD) in the general population, but its role as a predictive marker in HIV-positive patients remains unclear. Aim of the study was to evaluate whether hsCRP or other biomarkers are independent predictors of CVD risk in HIV-infected patients.Methods: Retrospective, nested case-control study. HIV-positive men and women (35-69 years of age) receiving combination antiretroviral therapy (cART) were included. Cases (n = 35) had a major CVD event. Controls (n = 74) free from CVD events for at least 5 years from starting ART were matched on diabetes and smoking. HsCRP, D-dimer, P-selectin, interleukin-6 (IL-6), tissue plasminogen activator, plasminogen activator inhibitor-1 levels were measured.Results: High hsCRP was associated with CVD risk, independently of traditional cardiovascular risk factors, HIV replication and the type of ART received at the time of sampling (adjusted odds ratio 8.00 [1.23-51.94] comparing >3.3 mg/L with

Original languageEnglish
Article number414
JournalBMC Infectious Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - Sep 3 2013

    Fingerprint

Keywords

  • Biomarkers
  • Cardiovascular disease
  • HIV
  • hsCRP

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

De Luca, A., de Gaetano Donati, K., Colafigli, M., Cozzi-Lepri, A., De Curtis, A., Gori, A., Sighinolfi, L., Giacometti, A., Capobianchi, M. R., D'Avino, A., Iacoviello, L., Cauda, R., & D'Arminio Monforte, A. (2013). The association of high-sensitivity c-reactive protein and other biomarkers with cardiovascular disease in patients treated for HIV: A nested case-control study. BMC Infectious Diseases, 13(1), [414]. https://doi.org/10.1186/1471-2334-13-414