Abstract
The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as
Original language | English |
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Pages (from-to) | 7213-7224 |
Number of pages | 12 |
Journal | International Journal of Molecular Sciences |
Volume | 15 |
Issue number | 5 |
DOIs | |
Publication status | Published - Apr 25 2014 |
Keywords
- Fibrosis
- Hepatitis C virus (HCV)
- Histology
- Interleukin 28B (IL28B) polymorphism
- Liver biopsy
- Natural history
- Necroinflammation
- Steatosis
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Spectroscopy
- Inorganic Chemistry
- Catalysis
- Molecular Biology
- Computer Science Applications
- Medicine(all)