The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent

Roberta D'Ambrosio; Alessio Aghemo; Raffaele De Francesco; Maria Grazia Rumi; Enrico Galmozzi; Stella De Nicola; Cristina Cheroni; Paul J. Clark; Guido Ronchi; Pietro Lampertico; Massimo Colombo

doi:10.3390/ijms15057213

The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent

Roberta D'Ambrosio, Alessio Aghemo, Raffaele De Francesco, Maria Grazia Rumi, Enrico Galmozzi, Stella De Nicola, Cristina Cheroni, Paul J. Clark, Guido Ronchi, Pietro Lampertico, Massimo Colombo

Research output: Contribution to journal › Article › peer-review

Abstract

The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as

Original language	English
Pages (from-to)	7213-7224
Number of pages	12
Journal	International Journal of Molecular Sciences
Volume	15
Issue number	5
DOIs	https://doi.org/10.3390/ijms15057213
Publication status	Published - Apr 25 2014

Keywords

Fibrosis
Hepatitis C virus (HCV)
Histology
Interleukin 28B (IL28B) polymorphism
Liver biopsy
Natural history
Necroinflammation
Steatosis

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Spectroscopy
Inorganic Chemistry
Catalysis
Molecular Biology
Computer Science Applications
Medicine(all)

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10.3390/ijms15057213

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D'Ambrosio, R., Aghemo, A., De Francesco, R., Rumi, M. G., Galmozzi, E., De Nicola, S., Cheroni, C., Clark, P. J., Ronchi, G., Lampertico, P., & Colombo, M. (2014). The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent. International Journal of Molecular Sciences, 15(5), 7213-7224. https://doi.org/10.3390/ijms15057213

The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent. / D'Ambrosio, Roberta ; Aghemo, Alessio; De Francesco, Raffaele; Rumi, Maria Grazia; Galmozzi, Enrico; De Nicola, Stella; Cheroni, Cristina; Clark, Paul J.; Ronchi, Guido; Lampertico, Pietro; Colombo, Massimo.

In: International Journal of Molecular Sciences, Vol. 15, No. 5, 25.04.2014, p. 7213-7224.

Research output: Contribution to journal › Article › peer-review

D'Ambrosio, R , Aghemo, A, De Francesco, R, Rumi, MG, Galmozzi, E, De Nicola, S, Cheroni, C, Clark, PJ, Ronchi, G, Lampertico, P & Colombo, M 2014, 'The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent', International Journal of Molecular Sciences, vol. 15, no. 5, pp. 7213-7224. https://doi.org/10.3390/ijms15057213

D'Ambrosio, Roberta ; Aghemo, Alessio ; De Francesco, Raffaele ; Rumi, Maria Grazia ; Galmozzi, Enrico ; De Nicola, Stella ; Cheroni, Cristina ; Clark, Paul J. ; Ronchi, Guido ; Lampertico, Pietro ; Colombo, Massimo. / The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent. In: International Journal of Molecular Sciences. 2014 ; Vol. 15, No. 5. pp. 7213-7224.

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abstract = "The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as ",

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AU - Galmozzi, Enrico

AU - De Nicola, Stella

AU - Cheroni, Cristina

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The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent

Abstract

Keywords

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