The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent

Roberta D'Ambrosio, Alessio Aghemo, Raffaele De Francesco, Maria Grazia Rumi, Enrico Galmozzi, Stella De Nicola, Cristina Cheroni, Paul J. Clark, Guido Ronchi, Pietro Lampertico, Massimo Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as

Original languageEnglish
Pages (from-to)7213-7224
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume15
Issue number5
DOIs
Publication statusPublished - Apr 25 2014

Keywords

  • Fibrosis
  • Hepatitis C virus (HCV)
  • Histology
  • Interleukin 28B (IL28B) polymorphism
  • Liver biopsy
  • Natural history
  • Necroinflammation
  • Steatosis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

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