The association of MYO9B gene in Italian patients with inflammatory bowel diseases

A. Latiano, O. Palmieri, M. R. Valvano, R. D'Incà, R. Caprilli, S. Cucchiara, G. C. Sturniolo, F. Bossa, A. Andriulli, V. Annese

Research output: Contribution to journalArticlepeer-review


Background: Variants of myosin IXB (MYO9B) gene, encoding for a motor protein implicated in epithelial permeability, have been recently associated with inflammatory bowel disease. Aims: To investigate the contribution of three polymorphisms of MYO9B gene for predisposition to Crohn's disease and ulcerative colitis, their association with clinical phenotypes, particularly intestinal permeability, and possible interaction with the CARD15 gene. Methods: 549 Crohn's disease patients, 658 ulcerative colitis patients and 674 controls were genotyped for the rs962917, rs1545620 and rs2305764 single nucleotide polymorphisms. Results: Highly significant genotypic association with Crohn's disease and ulcerative colitis was shown for all three single nucleotide polymorphisms, with odds ratio ranging from 1.5 to 1.7 (P-value:

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Issue number3
Publication statusPublished - Feb 2008

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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