The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys

L. Degenhardt, S. Saha, C.C.W. Lim, S. Aguilar-Gaxiola, A. Al-Hamzawi, J. Alonso, L.H. Andrade, E.J. Bromet, R. Bruffaerts, J.M. Caldas-de-Almeida, G. de Girolamo, S. Florescu, O. Gureje, J.M. Haro, G. Karam, G. Karam, V. Kovess-Masfety, S. Lee, J.-P. Lepine, V. MakanjuolaM.E. Medina-Mora, Z. Mneimneh, F. Navarro-Mateu, M. Piazza, J. Posada-Villa, N.A. Sampson, K.M. Scott, J.C. Stagnaro, M. Ten Have, K.S. Kendler, R.C. Kessler, J.J. McGrath, on behalf of the WHO World Mental Health Survey Collaborators

Research output: Contribution to journal › Article

Abstract

Background and aims: Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. Design, setting, participants and measurements: We used data from the World Health Organization World Mental Health surveys. A total of 30 902 adult respondents across 18 countries were assessed for (a) six types of life-time PEs, (b) a range of types of SU and DSM-IV SUDs and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. Findings: After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders [odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.2–2.0], extra-medical prescription drug use (OR = 1.5, 95% CI = 1.1–1.9), alcohol use (OR = 1.4, 95% CI = 1.1–1.7) and tobacco use (OR = 1.3, 95% CI = 1.0–1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR = 1.5, 95% CI = 1.2–1.9), alcohol use (OR = 1.3, 95% CI = 1.1–1.6) or cannabis use (OR = 1.3, 95% CI = 1.0–1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Conclusions: Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other. © 2017 Society for the Study of Addiction
Original languageEnglish
Pages (from-to)924-934
Number of pages11
JournalAddiction
Volume113
Issue number5
DOIs
Publication statusPublished - 2018

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Health Surveys
Substance-Related Disorders
Mental Health
Odds Ratio
Confidence Intervals
Mental Disorders
Alcohols
Tobacco Use
Global Health
Prescription Drugs
Cannabis
Survival Analysis
Age of Onset
Research
Diagnostic and Statistical Manual of Mental Disorders
Demography
Interviews

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Degenhardt, L., Saha, S., Lim, C. C. W., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., ... Collaborators, O. B. O. T. WHO. W. M. H. S. (2018). The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys. Addiction, 113(5), 924-934. https://doi.org/10.1111/add.14145

The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys. / Degenhardt, L.; Saha, S.; Lim, C.C.W.; Aguilar-Gaxiola, S.; Al-Hamzawi, A.; Alonso, J.; Andrade, L.H.; Bromet, E.J.; Bruffaerts, R.; Caldas-de-Almeida, J.M.; de Girolamo, G.; Florescu, S.; Gureje, O.; Haro, J.M.; Karam, G.; Karam, G.; Kovess-Masfety, V.; Lee, S.; Lepine, J.-P.; Makanjuola, V.; Medina-Mora, M.E.; Mneimneh, Z.; Navarro-Mateu, F.; Piazza, M.; Posada-Villa, J.; Sampson, N.A.; Scott, K.M.; Stagnaro, J.C.; Ten Have, M.; Kendler, K.S.; Kessler, R.C.; McGrath, J.J.; Collaborators, on behalf of the WHO World Mental Health Survey.

In: Addiction, Vol. 113, No. 5, 2018, p. 924-934.

Research output: Contribution to journal › Article

Degenhardt, L, Saha, S, Lim, CCW, Aguilar-Gaxiola, S, Al-Hamzawi, A, Alonso, J, Andrade, LH, Bromet, EJ, Bruffaerts, R, Caldas-de-Almeida, JM, de Girolamo, G, Florescu, S, Gureje, O, Haro, JM, Karam, G, Karam, G, Kovess-Masfety, V, Lee, S, Lepine, J-P, Makanjuola, V, Medina-Mora, ME, Mneimneh, Z, Navarro-Mateu, F, Piazza, M, Posada-Villa, J, Sampson, NA, Scott, KM, Stagnaro, JC, Ten Have, M, Kendler, KS, Kessler, RC, McGrath, JJ & Collaborators, OBOTWHOWMHS 2018, 'The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys', Addiction, vol. 113, no. 5, pp. 924-934. https://doi.org/10.1111/add.14145
Degenhardt L, Saha S, Lim CCW, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J et al. The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys. Addiction. 2018;113(5):924-934. https://doi.org/10.1111/add.14145
Degenhardt, L. ; Saha, S. ; Lim, C.C.W. ; Aguilar-Gaxiola, S. ; Al-Hamzawi, A. ; Alonso, J. ; Andrade, L.H. ; Bromet, E.J. ; Bruffaerts, R. ; Caldas-de-Almeida, J.M. ; de Girolamo, G. ; Florescu, S. ; Gureje, O. ; Haro, J.M. ; Karam, G. ; Karam, G. ; Kovess-Masfety, V. ; Lee, S. ; Lepine, J.-P. ; Makanjuola, V. ; Medina-Mora, M.E. ; Mneimneh, Z. ; Navarro-Mateu, F. ; Piazza, M. ; Posada-Villa, J. ; Sampson, N.A. ; Scott, K.M. ; Stagnaro, J.C. ; Ten Have, M. ; Kendler, K.S. ; Kessler, R.C. ; McGrath, J.J. ; Collaborators, on behalf of the WHO World Mental Health Survey. / The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys. In: Addiction. 2018 ; Vol. 113, No. 5. pp. 924-934.
@article{ecdd70ad0e4046b481e7aa273988533c,
title = "The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys",
abstract = "Background and aims: Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. Design, setting, participants and measurements: We used data from the World Health Organization World Mental Health surveys. A total of 30 902 adult respondents across 18 countries were assessed for (a) six types of life-time PEs, (b) a range of types of SU and DSM-IV SUDs and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. Findings: After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders [odds ratio (OR) = 1.6, 95{\%} confidence interval (CI) = 1.2–2.0], extra-medical prescription drug use (OR = 1.5, 95{\%} CI = 1.1–1.9), alcohol use (OR = 1.4, 95{\%} CI = 1.1–1.7) and tobacco use (OR = 1.3, 95{\%} CI = 1.0–1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR = 1.5, 95{\%} CI = 1.2–1.9), alcohol use (OR = 1.3, 95{\%} CI = 1.1–1.6) or cannabis use (OR = 1.3, 95{\%} CI = 1.0–1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Conclusions: Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other. {\circledC} 2017 Society for the Study of Addiction",
author = "L. Degenhardt and S. Saha and C.C.W. Lim and S. Aguilar-Gaxiola and A. Al-Hamzawi and J. Alonso and L.H. Andrade and E.J. Bromet and R. Bruffaerts and J.M. Caldas-de-Almeida and {de Girolamo}, G. and S. Florescu and O. Gureje and J.M. Haro and G. Karam and G. Karam and V. Kovess-Masfety and S. Lee and J.-P. Lepine and V. Makanjuola and M.E. Medina-Mora and Z. Mneimneh and F. Navarro-Mateu and M. Piazza and J. Posada-Villa and N.A. Sampson and K.M. Scott and J.C. Stagnaro and {Ten Have}, M. and K.S. Kendler and R.C. Kessler and J.J. McGrath and Collaborators, {on behalf of the WHO World Mental Health Survey}",
note = "Cited By :3 Export Date: 30 January 2019 CODEN: ADICE Correspondence Address: McGrath, J.J.; Queensland Centre for Mental Health Research, and Queensland Brain Institute, University of QueenslandAustralia; email: j.mcgrath@uq.edu.au",
year = "2018",
doi = "10.1111/add.14145",
language = "English",
volume = "113",
pages = "924--934",
journal = "Addiction",
issn = "0965-2140",
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TY - JOUR

T1 - The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys

AU - Degenhardt, L.

AU - Saha, S.

AU - Lim, C.C.W.

AU - Aguilar-Gaxiola, S.

AU - Al-Hamzawi, A.

AU - Alonso, J.

AU - Andrade, L.H.

AU - Bromet, E.J.

AU - Bruffaerts, R.

AU - Caldas-de-Almeida, J.M.

AU - de Girolamo, G.

AU - Florescu, S.

AU - Gureje, O.

AU - Haro, J.M.

AU - Karam, G.

AU - Karam, G.

AU - Kovess-Masfety, V.

AU - Lee, S.

AU - Lepine, J.-P.

AU - Makanjuola, V.

AU - Medina-Mora, M.E.

AU - Mneimneh, Z.

AU - Navarro-Mateu, F.

AU - Piazza, M.

AU - Posada-Villa, J.

AU - Sampson, N.A.

AU - Scott, K.M.

AU - Stagnaro, J.C.

AU - Ten Have, M.

AU - Kendler, K.S.

AU - Kessler, R.C.

AU - McGrath, J.J.

AU - Collaborators, on behalf of the WHO World Mental Health Survey

N1 - Cited By :3 Export Date: 30 January 2019 CODEN: ADICE Correspondence Address: McGrath, J.J.; Queensland Centre for Mental Health Research, and Queensland Brain Institute, University of QueenslandAustralia; email: j.mcgrath@uq.edu.au

PY - 2018

Y1 - 2018

N2 - Background and aims: Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. Design, setting, participants and measurements: We used data from the World Health Organization World Mental Health surveys. A total of 30 902 adult respondents across 18 countries were assessed for (a) six types of life-time PEs, (b) a range of types of SU and DSM-IV SUDs and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. Findings: After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders [odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.2–2.0], extra-medical prescription drug use (OR = 1.5, 95% CI = 1.1–1.9), alcohol use (OR = 1.4, 95% CI = 1.1–1.7) and tobacco use (OR = 1.3, 95% CI = 1.0–1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR = 1.5, 95% CI = 1.2–1.9), alcohol use (OR = 1.3, 95% CI = 1.1–1.6) or cannabis use (OR = 1.3, 95% CI = 1.0–1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Conclusions: Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other. © 2017 Society for the Study of Addiction

AB - Background and aims: Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. Design, setting, participants and measurements: We used data from the World Health Organization World Mental Health surveys. A total of 30 902 adult respondents across 18 countries were assessed for (a) six types of life-time PEs, (b) a range of types of SU and DSM-IV SUDs and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. Findings: After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders [odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.2–2.0], extra-medical prescription drug use (OR = 1.5, 95% CI = 1.1–1.9), alcohol use (OR = 1.4, 95% CI = 1.1–1.7) and tobacco use (OR = 1.3, 95% CI = 1.0–1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR = 1.5, 95% CI = 1.2–1.9), alcohol use (OR = 1.3, 95% CI = 1.1–1.6) or cannabis use (OR = 1.3, 95% CI = 1.0–1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Conclusions: Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other. © 2017 Society for the Study of Addiction

U2 - 10.1111/add.14145

DO - 10.1111/add.14145

M3 - Article

VL - 113

SP - 924

EP - 934

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 5

ER -

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