The atrial natriuretic peptide: A changing view

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The atrial natriuretic peptide (ANP), a component of the natriuretic peptide family, was discovered in 1981 when de Bold and his coworkers observed a natriuretic effect induced by infusion of atrial extracts in rats. Subsequently, an impressive amount of research has been carried out in order to identify the structure of the active peptide and its receptors, to characterize the biological functions of ANP and its involvement in the pathophysiology of diseases and, finally, its direct contributory role in the pathogenesis of some cardiovascular disorders. ANP plays a key role in the regulation of salt and water balance, as well as of blood pressure homeostasis. In addition, ANP is involved in the pathophysiology of hypertension and heart failure, and exerts a cellular antiproliferative effect in the cardiovascular system. More recently, a direct contributory role of ANP in the development of hypertension and of cerebrovascular disorders has been suggested by the use of molecular genetic approaches. Therefore, our understanding of the pathophysiologic relevance of ANP has changed over time, finally leading to the identification of ANP as a potential determinant of cardiovascular diseases, rather than as a simple marker of cardiac and vascular dysfunctions. This novel view of ANP may open interesting research pathways.

Original languageEnglish
Pages (from-to)1923-1931
Number of pages9
JournalJournal of Hypertension
Volume19
Issue number11
DOIs
Publication statusPublished - 2001

Fingerprint

Atrial Natriuretic Factor
Hypertension
Natriuretic Agents
Cerebrovascular Disorders
Natriuretic Peptides
Peptide Receptors
peptide A
Cardiovascular System
Research
Blood Vessels
Molecular Biology
Homeostasis
Cardiovascular Diseases
Heart Failure
Salts
Blood Pressure
Water

Keywords

  • Atrial natriuretic peptide
  • Cardiovascular remodelling
  • Genetics of cardiovascular diseases
  • Salt/water balance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

The atrial natriuretic peptide : A changing view. / Rubattu, Speranza; Volpe, Massimo.

In: Journal of Hypertension, Vol. 19, No. 11, 2001, p. 1923-1931.

Research output: Contribution to journalArticle

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