The attacker: target cell ratio and serum effects on in vitro cell mediated immunity

A. Mantovani, A. Veechi, F. Spreafico

Research output: Contribution to journalArticlepeer-review

Abstract

Sera collected from mice rejecting an allogeneic tumor and showing arming activity for normal splenocytes increased target cell lysis by immune cells when low (≤25:1) attacker:target cell ratios (A:T) were used but inhibited cytotoxicity at higher (100:1) A:T. The importance of this methodologic variable in studies of serum activity on cellular cytotoxicity is emphasized and the possible mechanisms are discussed.

Original languageEnglish
Pages (from-to)483-484
Number of pages2
JournalJournal of the National Cancer Institute
Volume55
Issue number2
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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