The Aurora B kinase in chromosome bi-orientation and spindle checkpoint signaling

Veronica Krenn, Andrea Musacchio

Research output: Contribution to journalArticle

Abstract

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation. As part of a macromolecular complex known as the chromosome passenger complex, Aurora B concentrates early during mitosis in the proximity of centromeres and kinetochores, the sites of attachment of chromosomes to spindle microtubules. There, it contributes to a number of processes that impart fidelity to cell division, including kinetochore stabilization, kinetochore-microtubule attachment, and the regulation of a surveillance mechanism named the spindle assembly checkpoint. In the regulation of these processes, Aurora B is the fulcrum of a remarkably complex network of interactions that feed back on its localization and activation state. In this review, we discuss the multiple roles of Aurora B during mitosis, focusing in particular on its role at centromeres and kinetochores. Many details of the network of interactions at these locations remain poorly understood, and we focus here on several crucial outstanding questions.

Original languageEnglish
Article number225
JournalFrontiers in Oncology
Volume5
Issue numberOCT
DOIs
Publication statusPublished - 2015

Keywords

  • Aurora B
  • Bi-orientation
  • Centromere
  • Chromosome passenger complex
  • Kinase
  • Kinetochore
  • Phosphatase
  • Spindle assembly checkpoint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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