The B side of rheumatoid arthritis pathogenesis

Stefano Alivernini, Barbara Tolusso, Anna Laura Fedele, Clara Di Mario, Gianfranco Ferraccioli, Elisa Gremese

Research output: Contribution to journalReview articlepeer-review


In the last years, a dramatic amount of research has been performedincreasing the knowledge about the biological mechanism underpinning Rheumatoid Arthritis (RA) inflammation, putting B lymphocytes in the center of RA pathogenesis. Nowadays, B cell phenotypes and autoantibodies positivity arose as important biomarkers in early and long-standing disease. Moreover, comparative analysis of peripheral blood and synovial tissue compartments enables the identification of novel physiopathological mechanisms promoting inflammation. In this narrative review we will discuss the biological relevance of B cell derived autoimmunity and in RA course, from disease onset to remission achievement.

Original languageEnglish
Pages (from-to)104465
JournalPharmacological Research
Publication statusPublished - Nov 2019


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