The basal nucleus of Meynert in patients with progressive supranuclear palsy

F. Tagliavini, G. Pilleri, C. Bouras, J. Constantinidis

Research output: Contribution to journalArticle

Abstract

The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrated ranging from 12.6% to 54.1%. In the PSP-Alzheimer patient, the loss of cells amounted to 73.8% and the surviving neurons exhibited a reduction in the nucleolar volume, suggesting a reduced protein synthetic capability. The involvement of the basal nucleus is therefore a usual anatomical feature of PSP. The damage is less severe than generally observed in Alzheimer's disease and biochemical studies are required to state whether this is accompanied by a substantial cholinergic deficit.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalNeuroscience Letters
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 27 1984

Keywords

  • basal nucleus of Meynert
  • neuronal counts
  • progressive supranuclear palsy
  • subcortical dementia

ASJC Scopus subject areas

  • Neuroscience(all)

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