The basal nucleus of Meynert in patients with progressive supranuclear palsy

F. Tagliavini, G. Pilleri, C. Bouras, J. Constantinidis

Research output: Contribution to journalArticle

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Abstract

The neuronal number and nucleolar volume of the magnocellular population of the basal nucleus of Meynert in 6 patients with progressive supranuclear palsy (PSP) - one associated with Alzheimer's disease - were compared with those of 5 controls. In the 5 typical PSP cases, an age-dependent neuronal loss was demonstrated ranging from 12.6% to 54.1%. In the PSP-Alzheimer patient, the loss of cells amounted to 73.8% and the surviving neurons exhibited a reduction in the nucleolar volume, suggesting a reduced protein synthetic capability. The involvement of the basal nucleus is therefore a usual anatomical feature of PSP. The damage is less severe than generally observed in Alzheimer's disease and biochemical studies are required to state whether this is accompanied by a substantial cholinergic deficit.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalNeuroscience Letters
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 27 1984

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Basal Nucleus of Meynert
Progressive Supranuclear Palsy
Alzheimer Disease
Basal Ganglia
Cholinergic Agents
Neurons
Population
Proteins

Keywords

  • basal nucleus of Meynert
  • neuronal counts
  • progressive supranuclear palsy
  • subcortical dementia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The basal nucleus of Meynert in patients with progressive supranuclear palsy. / Tagliavini, F.; Pilleri, G.; Bouras, C.; Constantinidis, J.

In: Neuroscience Letters, Vol. 44, No. 1, 27.01.1984, p. 37-42.

Research output: Contribution to journalArticle

Tagliavini, F. ; Pilleri, G. ; Bouras, C. ; Constantinidis, J. / The basal nucleus of Meynert in patients with progressive supranuclear palsy. In: Neuroscience Letters. 1984 ; Vol. 44, No. 1. pp. 37-42.
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