The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria

Simona Cabib, Tiziana Pascucci, Rossella Ventura, Valentino Romano, Stefano Puglisi-Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

Pahenu2 mice, created by chemically induced genetic mutation, are characterized by biochemical phenotypes closely resembling untreated human phenylketonuria (PKU). However, studies conducted in adult Pahenu2 mice have shown no indices of the severe mental retardation that characterizes untreated PKU. The present experiments explored recognition of novel spatial and nonspatial information in Pahenu2 mice by two nonassociative tests that do not use explicit reinforcement and avoid lengthy training. Moreover, we evaluated emotional reactivity by the Elevated Plus Maze. Finally, the performance of affected mutants was compared with that of their unaffected and heterozygous littermates and also with that of mice of the C57BL/6 (C57) inbred strain, an increasingly used background for genetic targeted organisms, and with DBA/2 (DBA) mice, known for their nonpathological deficits in spatial learning. The results demonstrated that mutant Pahenu2 mice are characterized by deficits involving both spatial and nonspatial recognition, that are not related to motor impairment or to high emotional reactivity to novelty. These results indicate that Pahenu2 mice show pathological cognitive deficits and support their use to test hypotheses about neurodevelopmental disturbances involved in mental retardation.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalBehavior Genetics
Volume33
Issue number3
DOIs
Publication statusPublished - May 2003

Keywords

  • Anxiety
  • Hyperphenylalaninemia
  • Neurodevelopment
  • Object recognition
  • Spatial novelty

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Fingerprint Dive into the research topics of 'The behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria'. Together they form a unique fingerprint.

Cite this