The beneficial role of intensive exercise on Parkinson disease progression

Giuseppe Frazzitta, Pietro Balbi, Roberto Maestri, Gabriella Bertotti, Natalia Boveri, Gianni Pezzoli

Research output: Contribution to journalArticlepeer-review


In the last decade, a considerable number of articles has shown that exercise is effective in improving motor performance in Parkinson disease. In particular, recent studies have focused on the efficacy of intensive exercise in achieving optimal results in the rehabilitation of patients with Parkinson disease. The effects of intensive exercise in promoting cell proliferation and neuronal differentiation in animal models are reported in a large cohort of studies, and these neuroplastic effects are probably related to increased expression of a variety of neurotrophic factors. The authors outline the relation between intensive exercises and neuroplastic activity on animal models of Parkinson disease and discuss the clinical results of different intensive strategies on motor performance and disease progression in patients with Parkinson disease.

Original languageEnglish
Pages (from-to)523-532
Number of pages10
JournalAmerican Journal of Physical Medicine and Rehabilitation
Issue number6
Publication statusPublished - 2013


  • Intensive Rehabilitation
  • Neuroplasticity
  • Parkinson Disease

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)


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