The bereitschaftspotential is abnormal in parkinson's disease

J. P R Dick, J. C. Rothwell, B. L. Day, R. Cantello, O. Buruma, M. Gioux, R. Benecke, A. Berardelli, P. D. Thompson, C. D. Marsden

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

The average Bereitschaftspotential (BP) preceding a rapid, self-paced voluntary extension movement of the index finger was recorded from 6 scalp locations in 14 patients with Parkinson's disease who had been withdrawn from their normal drug therapy for at least 12 h before testing. The amplitude of the potential was measured at the peak negativity (Nl) and 650 ms prior to this (NSI), and compared with that recorded in a group of 12 age-matched control subjects. The Nl amplitude was the same as in the normals, but the NS1 component was smaller in the patients, especially in midline leads As a result, the rise in the BP between the peak NS1 and Nl component (termed NS2) was larger in the patient group.The NS1 component of the BP is thought to reflect preparatory activity in the supplementary motor area (SMA) of cortex. Since the basal ganglia provide a major source of afferent input to SMA, the reduction in NS1 in the patients probably results from inadequate basal ganglia activation of SMA. The larger NS2 component may reflect extra activity in other brain areas to compensate for the reduced SMA activity.

Original languageEnglish
Pages (from-to)233-244
Number of pages12
JournalBrain
Volume112
Issue number1
DOIs
Publication statusPublished - Feb 1989

Fingerprint

Contingent Negative Variation
Parkinson's Disease
Parkinson disease
Motor Cortex
Parkinson Disease
Basal Ganglia
Drug therapy
drug therapy
Brain
Cortex
cortex
Scalp
Chemical activation
Fingers
Therapy
Activation
brain
Drugs
Motor Activity
Age Groups

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Dick, J. P. R., Rothwell, J. C., Day, B. L., Cantello, R., Buruma, O., Gioux, M., ... Marsden, C. D. (1989). The bereitschaftspotential is abnormal in parkinson's disease. Brain, 112(1), 233-244. https://doi.org/10.1093/brain/112.1.233

The bereitschaftspotential is abnormal in parkinson's disease. / Dick, J. P R; Rothwell, J. C.; Day, B. L.; Cantello, R.; Buruma, O.; Gioux, M.; Benecke, R.; Berardelli, A.; Thompson, P. D.; Marsden, C. D.

In: Brain, Vol. 112, No. 1, 02.1989, p. 233-244.

Research output: Contribution to journalArticle

Dick, JPR, Rothwell, JC, Day, BL, Cantello, R, Buruma, O, Gioux, M, Benecke, R, Berardelli, A, Thompson, PD & Marsden, CD 1989, 'The bereitschaftspotential is abnormal in parkinson's disease', Brain, vol. 112, no. 1, pp. 233-244. https://doi.org/10.1093/brain/112.1.233
Dick JPR, Rothwell JC, Day BL, Cantello R, Buruma O, Gioux M et al. The bereitschaftspotential is abnormal in parkinson's disease. Brain. 1989 Feb;112(1):233-244. https://doi.org/10.1093/brain/112.1.233
Dick, J. P R ; Rothwell, J. C. ; Day, B. L. ; Cantello, R. ; Buruma, O. ; Gioux, M. ; Benecke, R. ; Berardelli, A. ; Thompson, P. D. ; Marsden, C. D. / The bereitschaftspotential is abnormal in parkinson's disease. In: Brain. 1989 ; Vol. 112, No. 1. pp. 233-244.
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