The biological behaviour of basal cell carcinoma anatomo-clinical subtypes

Immunohistological, cytophotometric, and ultrastructural findings

G. F. Altomare, G. L. Capella, B. Biondo, V. Caputo, M. L. Repetti, S. Mangiarotti, C. Fracchiolla

Research output: Contribution to journalArticle

Abstract

Background. Basal cell carcinoma (BCC) is a locally invasive malignant tumor that can present in various anatomo-clinical forms (subtypes). An understanding of the basis of the differences in clinical and biological behaviour has not yet been provided. Aim. In this study we have employed a composite method of evaluation in order to evaluate biological differences of BCC subtvpes. In this view we have combined findings provided through electronmicroscopy, cytophotometry, and immunohistochemistry (CD1, CD3, CD4, CD25, HLA-DR: indexes of reactivity; TFr, EGFr, ICAM-1: indexes of proliferation/differentiation and immunoadherence). Immunohistochemical findings were quantified through a score in every sample, and scores were compared on statistical basis. Conclusions. A high cytophotometric Malignity Index, a torpid immunologic response, higher level of proliferative antigens, lower immunoadhesive differentiation: all of these findings distinguish superficial BCC among various subtypes of this neoplasia, providing a basis for the explanation of the typical sneaking and treacherous tendency to obstinate growth displayed by this fastidious variety of BCC.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalGiornale Italiano di Dermatologia e Venereologia
Volume130
Issue number2
Publication statusPublished - 1995

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Basal Cell Carcinoma
Cytophotometry
HLA-DR Antigens
Intercellular Adhesion Molecule-1
Neoplasms
Immunohistochemistry
Antigens
Growth

Keywords

  • basal cell carcinoma
  • cytophotometry
  • epidermal growth factor
  • immunohistochemistry
  • microscopy, electron
  • skin neoplasms
  • transferrin

ASJC Scopus subject areas

  • Dermatology

Cite this

The biological behaviour of basal cell carcinoma anatomo-clinical subtypes : Immunohistological, cytophotometric, and ultrastructural findings. / Altomare, G. F.; Capella, G. L.; Biondo, B.; Caputo, V.; Repetti, M. L.; Mangiarotti, S.; Fracchiolla, C.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 130, No. 2, 1995, p. 91-97.

Research output: Contribution to journalArticle

Altomare, G. F. ; Capella, G. L. ; Biondo, B. ; Caputo, V. ; Repetti, M. L. ; Mangiarotti, S. ; Fracchiolla, C. / The biological behaviour of basal cell carcinoma anatomo-clinical subtypes : Immunohistological, cytophotometric, and ultrastructural findings. In: Giornale Italiano di Dermatologia e Venereologia. 1995 ; Vol. 130, No. 2. pp. 91-97.
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AU - Repetti, M. L.

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AU - Fracchiolla, C.

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