Abstract
This paper reviews the biology of chromogranin A (CgA) and CgA-derived peptides and their possible role as markers for neuroendocrine tumours (NETs). NETs are neoplasms characterized by a low proliferation rate and, in some cases, a favourable prognosis. NETs often overproduce and release biologically active substances that are responsible for severe syndromes. The hormones and the biogenic amines released by biologically active NETs are currently used as biomarkers, but there is a need for sensitive markers for those NETs that are 'biochemically silent'. Circulating CgA levels have been demonstrated to be augmented in NET patients irrespective of the presence of syndromes related to hormone overproduction. Because of the high sensitivity and specificity of CgA, this glycoprotein can be successfully used in diagnosis, prognosis and follow-up of NETs. CgA blood evaluation seems of particular interest in the managements of the gastroenteropancreatic tract NETs and in carcinoids.
| Original language | English |
|---|---|
| Pages (from-to) | 3415-3427 |
| Number of pages | 13 |
| Journal | Anticancer Research |
| Volume | 19 |
| Issue number | 4 C |
| Publication status | Published - 1999 |
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Keywords
- Autonomous nervous system
- Carcinoid
- Chromogranin A
- Essential hypertension
- Islet-cell pancreas tumours
- Medullary thyroid carcinoma
- Neuroblastoma
- Neuroendocrine tumours
- Pancreastatin
- Phaeochromocytoma
- Small cell lung cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
The biological characteristics of chromogranin A and its role as a circulating marker in neuroendocrine tumours. / Ferrari, Leonardo; Seregni, Ettore; Bajetta, Emilio; Martinetti, Antonia; Bombardieri, Emilio.
In: Anticancer Research, Vol. 19, No. 4 C, 1999, p. 3415-3427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The biological characteristics of chromogranin A and its role as a circulating marker in neuroendocrine tumours
AU - Ferrari, Leonardo
AU - Seregni, Ettore
AU - Bajetta, Emilio
AU - Martinetti, Antonia
AU - Bombardieri, Emilio
PY - 1999
Y1 - 1999
N2 - This paper reviews the biology of chromogranin A (CgA) and CgA-derived peptides and their possible role as markers for neuroendocrine tumours (NETs). NETs are neoplasms characterized by a low proliferation rate and, in some cases, a favourable prognosis. NETs often overproduce and release biologically active substances that are responsible for severe syndromes. The hormones and the biogenic amines released by biologically active NETs are currently used as biomarkers, but there is a need for sensitive markers for those NETs that are 'biochemically silent'. Circulating CgA levels have been demonstrated to be augmented in NET patients irrespective of the presence of syndromes related to hormone overproduction. Because of the high sensitivity and specificity of CgA, this glycoprotein can be successfully used in diagnosis, prognosis and follow-up of NETs. CgA blood evaluation seems of particular interest in the managements of the gastroenteropancreatic tract NETs and in carcinoids.
AB - This paper reviews the biology of chromogranin A (CgA) and CgA-derived peptides and their possible role as markers for neuroendocrine tumours (NETs). NETs are neoplasms characterized by a low proliferation rate and, in some cases, a favourable prognosis. NETs often overproduce and release biologically active substances that are responsible for severe syndromes. The hormones and the biogenic amines released by biologically active NETs are currently used as biomarkers, but there is a need for sensitive markers for those NETs that are 'biochemically silent'. Circulating CgA levels have been demonstrated to be augmented in NET patients irrespective of the presence of syndromes related to hormone overproduction. Because of the high sensitivity and specificity of CgA, this glycoprotein can be successfully used in diagnosis, prognosis and follow-up of NETs. CgA blood evaluation seems of particular interest in the managements of the gastroenteropancreatic tract NETs and in carcinoids.
KW - Autonomous nervous system
KW - Carcinoid
KW - Chromogranin A
KW - Essential hypertension
KW - Islet-cell pancreas tumours
KW - Medullary thyroid carcinoma
KW - Neuroblastoma
KW - Neuroendocrine tumours
KW - Pancreastatin
KW - Phaeochromocytoma
KW - Small cell lung cancer
UR - http://www.scopus.com/inward/record.url?scp=0033452512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033452512&partnerID=8YFLogxK
M3 - Article
C2 - 10629629
AN - SCOPUS:0033452512
VL - 19
SP - 3415
EP - 3427
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4 C
ER -