The biological relevance of polykaryons in the immune response.

S. Fais, V. L. Burgio, M. R. Capobianchi, S. Gessani, F. Pallone, F. Belardelli

Research output: Contribution to journalArticlepeer-review


Peripheral blood monocyte-derived multinucleated giant cells are a well-known feature of chronic inflammatory conditions. Similarly, virus-induced syncytia derived from CD4+ cells are considered to be typical of human immunodeficiency virus infection under culture conditions. Here, Stefano Fais and colleagues summarize recent experimental results comparing the mechanisms underlying the formation and fate of these two different polykaryons, discussing their putative role in the immune response.

Original languageEnglish
Pages (from-to)522-527
Number of pages6
JournalImmunology Today
Issue number11
Publication statusPublished - Nov 1997

ASJC Scopus subject areas

  • Immunology


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