The biological significance of soluble interleukin-2 receptors in solid tumors

P. Lissoni, S. Barni, F. Rovelli, S. Viviani, G. J M Maestroni, A. Conti, G. Tancini

Research output: Contribution to journalArticle

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Abstract

In an attempt to further understand the biological significance of soluble IL-2 receptors (sIL-2R) in solid tumors, we have evaluated 160 cancer patients (breast: 40; lung: 66; colon: 18; stomach: 22; uterine cervix: 14) and 58 healthy subjects, as controls. Serum mean levels of sIL-2R, measured with an enzyme immunoassay, were significantly higher in cancer patients than in controls. Metastatic cancer patients showed significantly higher values than the non-metastatic ones; this difference was significant in all tumor histotypes, except small cell lung carcinoma. Moreover, in 15 patients in whom sIL-2R were evaluated either before or after radical surgery, a significant surgery-induced increase in sIL-R mean values was seen. Finally, the chemotherapy-induced rise in sIL-2R appeared to be associated with a lack of clinical response. These results seem to suggest that sIL-2R may be a marker of host biological response in patients with solid tumors, the significance of which needs further investigation.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalEuropean Journal of Cancer and Clinical Oncology
Volume26
Issue number1
DOIs
Publication statusPublished - 1990

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Interleukin-2 Receptors
Neoplasms
Small Cell Lung Carcinoma
Immunoenzyme Techniques
Cervix Uteri
Stomach
Healthy Volunteers
Colon
Biomarkers
Breast Neoplasms
Drug Therapy
Lung
Serum

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The biological significance of soluble interleukin-2 receptors in solid tumors. / Lissoni, P.; Barni, S.; Rovelli, F.; Viviani, S.; Maestroni, G. J M; Conti, A.; Tancini, G.

In: European Journal of Cancer and Clinical Oncology, Vol. 26, No. 1, 1990, p. 33-36.

Research output: Contribution to journalArticle

Lissoni, P. ; Barni, S. ; Rovelli, F. ; Viviani, S. ; Maestroni, G. J M ; Conti, A. ; Tancini, G. / The biological significance of soluble interleukin-2 receptors in solid tumors. In: European Journal of Cancer and Clinical Oncology. 1990 ; Vol. 26, No. 1. pp. 33-36.
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