The biological tumor markers' myopia

a model with CA 125 and second-look in ovarian cancer.

F. Zanaboni, G. Accinelli, P. Colombo, G. Jelmoni, C. Morandi, S. Pedronetto, R. Sbernini, G. Bolis

Research output: Contribution to journalArticle

Abstract

Preoperative CA 125 levels were measured in 36 patients with advanced epithelial ovarian carcinoma in clinical response undergoing a second-look operation. All the patients had positive levels (greater than 35 U/ml) of this tumor marker at diagnosis. The correlation between antigen levels and disease status at surgery revealed a sensitivity of this assay of 0.55 (only 11/20 patients still with tumor had positive levels) and a specificity of 0.94 (15/16 patients with no tumor had less than 35 U/ml). The predictive value of a positive test was 0.92. This method unfortunately proved unable to recognize microscopic residual tumor burden, less than 0.5 cm.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalInternational Journal of Biological Markers
Volume2
Issue number2
Publication statusPublished - May 1987

Fingerprint

Myopia
Tumor Biomarkers
Ovarian Neoplasms
Tumors
Surgery
Assays
Residual Neoplasm
Tumor Burden
Antigens
Neoplasms
Carcinoma

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

Zanaboni, F., Accinelli, G., Colombo, P., Jelmoni, G., Morandi, C., Pedronetto, S., ... Bolis, G. (1987). The biological tumor markers' myopia: a model with CA 125 and second-look in ovarian cancer. International Journal of Biological Markers, 2(2), 105-108.

The biological tumor markers' myopia : a model with CA 125 and second-look in ovarian cancer. / Zanaboni, F.; Accinelli, G.; Colombo, P.; Jelmoni, G.; Morandi, C.; Pedronetto, S.; Sbernini, R.; Bolis, G.

In: International Journal of Biological Markers, Vol. 2, No. 2, 05.1987, p. 105-108.

Research output: Contribution to journalArticle

Zanaboni, F, Accinelli, G, Colombo, P, Jelmoni, G, Morandi, C, Pedronetto, S, Sbernini, R & Bolis, G 1987, 'The biological tumor markers' myopia: a model with CA 125 and second-look in ovarian cancer.', International Journal of Biological Markers, vol. 2, no. 2, pp. 105-108.
Zanaboni F, Accinelli G, Colombo P, Jelmoni G, Morandi C, Pedronetto S et al. The biological tumor markers' myopia: a model with CA 125 and second-look in ovarian cancer. International Journal of Biological Markers. 1987 May;2(2):105-108.
Zanaboni, F. ; Accinelli, G. ; Colombo, P. ; Jelmoni, G. ; Morandi, C. ; Pedronetto, S. ; Sbernini, R. ; Bolis, G. / The biological tumor markers' myopia : a model with CA 125 and second-look in ovarian cancer. In: International Journal of Biological Markers. 1987 ; Vol. 2, No. 2. pp. 105-108.
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