Abstract
Tuberculosis (TB) still poses a major threat to mankind and during the last thirty years we have seen a recrudescence of the disease even in countries where TB was thought to be conquered. It is common opinion that more effective control tools such as new diagnostics, a new vaccine and new drugs are urgently needed to control the global pandemic, though the so far insufficient understanding of the Mycobacterium tuberculosis (Mtb) mechanism of pathogenesis is a major obstacle for the development of these control tools. In this review, we will summarize the recent advancement in the understanding of Mtb biology and on the pathogenesis of Mtb infection with emphasis on latent infection, with the change in paradigm of the last few years where the dichotomy between latent and active disease has been reconsidered in favor of a dynamic equilibrium between the host and the bacilli, encompassing a continuous spectrum of conditions that has been named TB spectrum. Implications for the diagnosis and control of disease in certain population will also be discussed.
| Original language | English |
|---|---|
| Article number | e2013070 |
| Journal | Mediterranean Journal of Hematology and Infectious Diseases |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 |
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ASJC Scopus subject areas
- Hematology
- Infectious Diseases
Cite this
The biology of mycobacterium tuberculosis infection. / Delogu, Giovanni; Sali, Michela; Fadda, Giovanni.
In: Mediterranean Journal of Hematology and Infectious Diseases, Vol. 5, No. 1, e2013070, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The biology of mycobacterium tuberculosis infection
AU - Delogu, Giovanni
AU - Sali, Michela
AU - Fadda, Giovanni
PY - 2013
Y1 - 2013
N2 - Tuberculosis (TB) still poses a major threat to mankind and during the last thirty years we have seen a recrudescence of the disease even in countries where TB was thought to be conquered. It is common opinion that more effective control tools such as new diagnostics, a new vaccine and new drugs are urgently needed to control the global pandemic, though the so far insufficient understanding of the Mycobacterium tuberculosis (Mtb) mechanism of pathogenesis is a major obstacle for the development of these control tools. In this review, we will summarize the recent advancement in the understanding of Mtb biology and on the pathogenesis of Mtb infection with emphasis on latent infection, with the change in paradigm of the last few years where the dichotomy between latent and active disease has been reconsidered in favor of a dynamic equilibrium between the host and the bacilli, encompassing a continuous spectrum of conditions that has been named TB spectrum. Implications for the diagnosis and control of disease in certain population will also be discussed.
AB - Tuberculosis (TB) still poses a major threat to mankind and during the last thirty years we have seen a recrudescence of the disease even in countries where TB was thought to be conquered. It is common opinion that more effective control tools such as new diagnostics, a new vaccine and new drugs are urgently needed to control the global pandemic, though the so far insufficient understanding of the Mycobacterium tuberculosis (Mtb) mechanism of pathogenesis is a major obstacle for the development of these control tools. In this review, we will summarize the recent advancement in the understanding of Mtb biology and on the pathogenesis of Mtb infection with emphasis on latent infection, with the change in paradigm of the last few years where the dichotomy between latent and active disease has been reconsidered in favor of a dynamic equilibrium between the host and the bacilli, encompassing a continuous spectrum of conditions that has been named TB spectrum. Implications for the diagnosis and control of disease in certain population will also be discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84902593923&partnerID=8YFLogxK
U2 - 10.4084/mjhid.2013.070
DO - 10.4084/mjhid.2013.070
M3 - Article
AN - SCOPUS:84902593923
VL - 5
JO - Mediterranean Journal of Hematology and Infectious Diseases
JF - Mediterranean Journal of Hematology and Infectious Diseases
SN - 2035-3006
IS - 1
M1 - e2013070
ER -