The blood peptidome: A higher dimension of information content for cancer biomarker discovery

Emanuel F. Petricoin, Claudio Belluco, Robyn P. Araujo, Lance A. Liotta

Research output: Contribution to journalArticle

Abstract

The low-molecular-weight range of the circulatory proteome is termed the 'peptidome', and could be a rich source of cancer-specific diagnostic information because it is a 'recording' of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin.Measuring panels of peptidome markers might be more sensitive and specific than conventional biomarker approaches. We discuss the advantages and disadvantages of various methods for studying the peptidome.

Original languageEnglish
Pages (from-to)961-967
Number of pages7
JournalNature Reviews Cancer
Volume6
Issue number12
DOIs
Publication statusPublished - Dec 9 2006

ASJC Scopus subject areas

  • Cancer Research

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