The bone marrow represents an enrichment site of specific T lymphocytes against filamentous fungi

Daniela Vallerini, Giovanni Riva, Patrizia Barozzi, Fabio Forghieri, Ivana Lagreca, Chiara Quadrelli, Monica Morselli, Paola Bresciani, Angela Cuoghi, Valeria Coluccio, Monica MacCaferri, Ambra Paolini, Elisabetta Colaci, Roberto Marasca, Franco Narni, Jean Paul Latgè, Luigina Romani, Patrizia Comoli, Daniele Campioli, Tommaso TrentiMario Luppi, Leonardo Potenza

Research output: Contribution to journalArticle

Abstract

Bone marrow has already been described as an enrichment site for several antigen-specific T lymphocytes, but the presence of mould-specific T cells has never been investigated in the bone marrow. We have previously demonstrated that mould-specific T cells emerge in the peripheral blood of patients with invasive fungal infections (IFI) but tend to become undetectable after disease resolution. In seven patients with a history of IFI, we investigated the presence of mould-specific T cells secreting different cytokines in bone marrow and peripheral blood paired samples. The results showed that the frequencies of mould-specific T cells secreting the protective cytokine IFNI3 are significantly higher in bone marrow (BM) and are mainly represented by CD8+ T lymphocytes with effector phenotype. A putative disappearance of such protective BM responses after myeloablative therapy could contribute to the increased risk of IFI in hematologic patients.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalMedical Mycology
Volume54
Issue number3
DOIs
Publication statusPublished - Jan 14 2016

Keywords

  • antigen-specific T cells
  • bone marrow
  • Invasive Aspergillosis
  • Invasive Mucormycosis

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

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    Vallerini, D., Riva, G., Barozzi, P., Forghieri, F., Lagreca, I., Quadrelli, C., Morselli, M., Bresciani, P., Cuoghi, A., Coluccio, V., MacCaferri, M., Paolini, A., Colaci, E., Marasca, R., Narni, F., Latgè, J. P., Romani, L., Comoli, P., Campioli, D., ... Potenza, L. (2016). The bone marrow represents an enrichment site of specific T lymphocytes against filamentous fungi. Medical Mycology, 54(3), 327-332. https://doi.org/10.1093/mmy/myv107