The Bovine Pericardium Matrix in Immediate Implant-Based Breast Reconstruction

Fabio Castagnetti, Chiara Bertani, Monica Foroni, Giuseppe Falco, Eugenio Cenini, Filomena De Bonis, Guglielmo Ferrari

Research output: Contribution to journalArticlepeer-review


Background: Acellular dermal matrices have been introduced to optimize direct-to-implant breast reconstruction. We selected a bovine pericardium noncross-linked matrix. Methods: The study consists in the retrospective analysis of 123 patients (141 breasts) who underwent conservative mastectomy and immediate implant-based breast reconstruction with bovine pericardium matrix Veritas® from March 2012 to October 2017. Results: The overall rates of early and late complications, after a median follow-up of 51.84 months, were, respectively, 37.6% and 24.1%. The most noticeable early complications were flap ischemia [n = 39 (27.7%)], hematoma [n = 5 (3.6%)], marginal skin flap necrosis [n = 5 (3.6%)] and dehiscence of the surgical wound [n = 2 (1.4%)]. The most common late complications were rippling [n = 18 (12.7%)] and seroma [n = 4 (2.8%)]. The rate of clinically relevant capsular contracture was low: 12.1% (n = 17) presented grade II and only 2.1%% (n = 3) grade III. Implant substitution became necessary for five patients (3.6%). Early complications occurred more frequently in patients undergoing therapeutic mastectomy (p = 0.031). Patients undergoing preoperative radiotherapy more frequently developed late complications (p = 0.012). A clinically relevant capsular contracture (grade II–III) was found in higher average patients age (p = 0.0019). The left side developed less frequently late complications except for rippling (p = 0.002). Rippling occurred more frequently in patients who sustained a nipple skin-sparing mastectomy (p = 0.035). Conclusion: Our results further support the safety of Veritas® in immediate implant-based breast reconstruction. Level of Evidence IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors

Original languageEnglish
Pages (from-to)2051-2060
Number of pages10
JournalAesthetic Plastic Surgery
Issue number6
Publication statusPublished - Dec 2020


  • Bovine pericardium
  • Direct-to-implant
  • Immediate breast reconstruction

ASJC Scopus subject areas

  • Surgery


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